Bglap - bone gamma carboxyglutamate protein Gene

Also Known as OC; BGP; OG1; mOC-A; Bglap1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12096

Summary

This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two Other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]

Bglap Products (1)

mRNA Protein Name
NM_007541.3 NP_031567.1 osteocalcin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
17693256 MGI
enables hormone activity IMP
IMP: Inferred from mutant phenotype
20655470 MGI
enables structural constituent of bone IMP
IMP: Inferred from mutant phenotype
8684484 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IDA
IDA: Inferred from direct assay
24074871 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
24074871 MGI
acts upstream of or within cellular response to BMP stimulus IDA
IDA: Inferred from direct assay
21324897 MGI
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
17693256 MGI
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17693256 MGI
involved in cognition IDA
IDA: Inferred from direct assay
28851741 MGI
involved in cognition IMP
IMP: Inferred from mutant phenotype
28851741 MGI
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
17693256 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
17693256 MGI
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
24074871 MGI
involved in negative regulation of bone development IMP
IMP: Inferred from mutant phenotype
8684484 MGI
involved in positive regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
24074871 MGI
involved in positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
24074871 MGI
involved in regulation of testosterone biosynthetic process IDA
IDA: Inferred from direct assay
21333348 MGI
involved in regulation of testosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
21333348 MGI
involved in type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
17693256 MGI
involved in type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
17693256 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15030764 MGI
is active in extracellular region IDA
IDA: Inferred from direct assay
20655470 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
21324897 MGI
is active in extracellular region IMP
IMP: Inferred from mutant phenotype
20655470 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

osteocalcin

  • bone Gla protein

  • bone gamma carboxyglutamate protein 1

  • gamma-carboxyglutamic acid-containing protein

Recombinant Bglap Proteins

Cat. No. Product Name Accession Purity
HY-P72103 BGLAP Protein, Mouse (His-SUMO) P86546 (Y50-I95) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10126 Osteocalcin, bovine / Unkown
HY-RS01488 BGLAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18166 Bglap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24640 Bglap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bglap NCBI NCBI:632