Bik - BCL2-interacting killer Gene

Also Known as Blk; Nbk; Biklk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12124

Summary

Predicted to enable BH domain binding activity. Acts upstream of or within apoptotic mitochondrial changes; male gonad development; and spermatogenesis. Located in mitochondrial envelope. Is expressed in heart; liver; lung; metanephros; and testis. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate Cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Apr 2022]

Bik Products (1)

mRNA Protein Name
NM_007546.2 NP_031572.1 bcl-2-interacting killer

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9525867 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: Inferred from direct assay
9525867 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
16270031 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
16270031 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial envelope IDA
IDA: Inferred from direct assay
9525867 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl-2-interacting killer

  • apoptosis inducer NBK

  • bik-like killer protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-50868 Bafetinib 99.18% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5341 Bik BH3 99.05% Unkown
HY-E70861 SIK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS01503 BIK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17788 Bik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24255 Bik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bik NCBI NCBI:638