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Bmi1 - Bmi1 polycomb ring finger oncogene Gene

Also Known as Bmi-1; Pcgf4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12151

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; histone modification; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PcG protein complex and ubiquitin Ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Bmi1 Products (1)

mRNA	Protein	Name
NM_007552.4	NP_031578.2	polycomb complex protein BMI-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	16359901	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22770845	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9367786	MGI
enables ubiquitin-protein transferase activator activity	IDA IDA: Inferred from direct assay	16359901	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	24105743	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	7926765	MGI
acts upstream of or within chromatin organization	IDA IDA: Inferred from direct assay	16359901	MGI
acts upstream of or within chromatin organization	IGI IGI: Inferred from genetic interaction	16687444	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within humoral immune response	IMP IMP: Inferred from mutant phenotype	7926765	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9312051	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24105743	MGI
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	15964995	MGI
involved in positive regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	15964995	MGI
acts upstream of or within regulation of adaxial/abaxial pattern formation	IGI IGI: Inferred from genetic interaction	17107999	MGI
acts upstream of or within rostrocaudal neural tube patterning	IMP IMP: Inferred from mutant phenotype	8887324	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	7926765	MGI
acts upstream of or within somatic stem cell division	IMP IMP: Inferred from mutant phenotype	12714971	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	16359901	MGI
part of PcG protein complex	IDA IDA: Inferred from direct assay	16624538	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	18311137	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	12183370	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17107999	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
polycomb complex protein BMI-1	B lymphoma Mo-MLV insertion region 1 polycomb group RING finger protein 4 polycomb group ring finger 4

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112041	Unesbulin	Inhibitor	99.17%	Phase 3

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15888	PTC-209	Inhibitor	99.76%	Unkown
HY-160924	MS147	Degrader	98.31%	Unkown
HY-103696	PTC-028	Inhibitor	98.0%	Unkown
HY-15888A	PTC-209 hydrobromide	Inhibitor	99.02%	Unkown
HY-143655	QW24	Inhibitor	/	Unkown
HY-143658	SH498	Inhibitor	/	Unkown
HY-172617	APD-94	Inhibitor	/	Unkown
HY-N0992	1,6,7-Trihydroxyxanthone	Inhibitor	/	Unkown
HY-183634	BMI1/RING1B ligand-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmi1	NCBI	NCBI:648