Bmp4 - bone morphogenetic protein 4 Gene

Also Known as Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12159

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]

Bmp4 Products (2)

mRNA Protein Name
NM_001316360.1 NP_001303289.1 bone morphogenetic protein 4 preproprotein
NM_007554.3 NP_031580.2 bone morphogenetic protein 4 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
15381701 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12897139 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
14623234 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
15975920 MGI
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of ameloblast differentiation IDA
IDA: Inferred from direct assay
15525533 MGI
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
14681194 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
16916379 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
10964473 MGI
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
NOT involved in apoptotic process involved in endocardial cushion morphogenesis IMP
IMP: Inferred from mutant phenotype
18924235 MGI
acts upstream of or within blood vessel development IDA
IDA: Inferred from direct assay
17881493 MGI
acts upstream of or within bone development IDA
IDA: Inferred from direct assay
8358941 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
11401393 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
17522159 MGI
acts upstream of or within bud elongation involved in lung branching IDA
IDA: Inferred from direct assay
18367557 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
14681194 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
9268572 MGI
NOT involved in cardiac jelly development IMP
IMP: Inferred from mutant phenotype
18924235 MGI
involved in cardiac muscle cell differentiation IGI
IGI: Inferred from genetic interaction
21145505 MGI
NOT involved in cardiac right ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
18924235 MGI
acts upstream of or within cell fate commitment IDA
IDA: Inferred from direct assay
12421925 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
18028901 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
7848824 MGI
acts upstream of chondrocyte differentiation IDA
IDA: Inferred from direct assay
17481601 MGI
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20059955 MGI
involved in coronary vasculature development IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within cranial suture morphogenesis IDA
IDA: Inferred from direct assay
9477322 MGI
involved in deltoid tuberosity development IMP
IMP: Inferred from mutant phenotype
20059955 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
15218525 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
9268572 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
10964473 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
9664686 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
9664686 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
15716346 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IGI
IGI: Inferred from genetic interaction
9664686 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IMP
IMP: Inferred from mutant phenotype
9664686 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
16712836 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
16712836 MGI
involved in endocardial cushion development IMP
IMP: Inferred from mutant phenotype
18924235 MGI
involved in endochondral ossification IMP
IMP: Inferred from mutant phenotype
20059955 MGI
acts upstream of or within endoderm development IDA
IDA: Inferred from direct assay
24835669 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
18028901 MGI
NOT involved in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: Inferred from mutant phenotype
18924235 MGI
acts upstream of or within epithelial-mesenchymal cell signaling IDA
IDA: Inferred from direct assay
8104708 MGI
acts upstream of or within epithelium development IDA
IDA: Inferred from direct assay
8898217 MGI
acts upstream of or within erythrocyte differentiation IDA
IDA: Inferred from direct assay
15591122 MGI
NOT involved in eye development IGI
IGI: Inferred from genetic interaction
16154126 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
14681194 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
9268572 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
11784076 MGI
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
15289457 MGI
involved in glomerular capillary formation IMP
IMP: Inferred from mutant phenotype
18272846 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12975322 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IDA
IDA: Inferred from direct assay
7799920 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IGI
IGI: Inferred from genetic interaction
17555714 MGI
involved in kidney development IGI
IGI: Inferred from genetic interaction
16154126 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within lens induction in camera-type eye IMP
IMP: Inferred from mutant phenotype
9851982 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16414041 MGI
acts upstream of or within mammary gland formation IMP
IMP: Inferred from mutant phenotype
17071745 MGI
involved in membranous septum morphogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within mesoderm formation IDA
IDA: Inferred from direct assay
7799920 MGI
acts upstream of or within mesodermal cell differentiation IDA
IDA: Inferred from direct assay
7799920 MGI
acts upstream of or within mesodermal cell fate determination IMP
IMP: Inferred from mutant phenotype
7657163 MGI
acts upstream of or within metanephros development IDA
IDA: Inferred from direct assay
12631064 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
12631064 MGI
NOT involved in muscular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
18924235 MGI
involved in negative regulation of branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
15634693 MGI
acts upstream of or within negative regulation of branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
21281623 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
17481601 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
18028901 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11401393 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
11493558 MGI
acts upstream of or within negative regulation of prostatic bud formation IDA
IDA: Inferred from direct assay
18393306 MGI
acts upstream of or within negative regulation of prostatic bud formation IMP
IMP: Inferred from mutant phenotype
11401393 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9585504 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within neural tube closure IDA
IDA: Inferred from direct assay
19850029 MGI
acts upstream of or within neuron fate commitment IDA
IDA: Inferred from direct assay
17698011 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
17698011 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IDA
IDA: Inferred from direct assay
15525533 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
16179481 MGI
acts upstream of or within organ induction IMP
IMP: Inferred from mutant phenotype
9806931 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: Inferred from direct assay
15381701 MGI
involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
21145505 MGI
involved in outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within pericyte cell differentiation IDA
IDA: Inferred from direct assay
16546160 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
9806931 MGI
involved in positive regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
20059955 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18692041 MGI
involved in positive regulation of branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
17350185 MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
23863481 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
24603907 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18692041 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15070745 MGI
involved in positive regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
20406889 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
15525533 MGI
involved in positive regulation of epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
23863481 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
19001364 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18622394 MGI
involved in positive regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
21145505 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
9786991 MGI
involved in positive regulation of odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
29148101 MGI
acts upstream of or within positive regulation of ossification IDA
IDA: Inferred from direct assay
8358941 MGI
acts upstream of positive effect positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
34995814 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18692041 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8104708 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
8898217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18692041 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of prostatic bud formation IMP
IMP: Inferred from mutant phenotype
11401393 MGI
involved in pulmonary valve morphogenesis IMP
IMP: Inferred from mutant phenotype
15070745 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15772937 MGI
acts upstream of or within regulation of cartilage development IDA
IDA: Inferred from direct assay
20501701 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
15525533 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
10704389 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11436557 MGI
acts upstream of or within regulation of mesodermal cell differentiation IDA
IDA: Inferred from direct assay
17881493 MGI
acts upstream of or within regulation of mesodermal cell differentiation IGI
IGI: Inferred from genetic interaction
17881493 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IMP
IMP: Inferred from mutant phenotype
11401393 MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
9244299 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
17881493 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
17881493 MGI
acts upstream of or within regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
15800000 MGI
acts upstream of or within renal system process IMP
IMP: Inferred from mutant phenotype
9268572 MGI
acts upstream of or within skeletal system development IDA
IDA: Inferred from direct assay
14654219 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15936012 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
16546160 MGI
involved in smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
12631064 MGI
acts upstream of or within specification of animal organ position IMP
IMP: Inferred from mutant phenotype
17071745 MGI
involved in specification of segmental identity, mandibular segment IDA
IDA: Inferred from direct assay
11784076 MGI
acts upstream of or within telencephalon regionalization IDA
IDA: Inferred from direct assay
16855091 MGI
acts upstream of or within telencephalon regionalization IGI
IGI: Inferred from genetic interaction
11719201 MGI
involved in tendon cell differentiation IMP
IMP: Inferred from mutant phenotype
20059955 MGI
acts upstream of or within trachea formation IMP
IMP: Inferred from mutant phenotype
18692041 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8898217 MGI
involved in ureter morphogenesis IMP
IMP: Inferred from mutant phenotype
17442697 MGI
acts upstream of or within ureteric bud development IDA
IDA: Inferred from direct assay
12631064 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
12631064 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
17881493 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
8358941 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17481601 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 4

  • bone morphogenetic protein 2B

Recombinant Bmp4 Proteins

Cat. No. Product Name Accession Purity
HY-P74379 BMP-4 Protein, Mouse (HEK293, Fc) P21275 (S293-R408) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700163AF Animal-Free BMP-4 Protein, Mouse (His) P21275 (K303-R408) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-16712 LDN-214117 Inhibitor 99.54% Unkown
HY-18961 PD 407824 Inhibitor 99.00% Unkown
HY-147372 SJ000063181 Activator 98.92% Unkown
HY-P10710A BMP-4 (15-24) acetate Inhibitor 99.30% Unkown
HY-N9409 2-Hydroxymelatonin / Unkown
HY-P10710 BMP-4 (15-24) Inhibitor / Unkown
HY-RS01539 BMP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179400 LDN-193688 Inhibitor / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-RS16511 Bmp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22943 Bmp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991879 Anti-BMP-4 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp4 NCBI NCBI:652