Gdf2 - growth differentiation factor 2 Gene

Also Known as Bmp9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12165

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]

Gdf2 Products (1)

mRNA Protein Name
NM_019506.4 NP_062379.3 growth/differentiation factor 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20406889 MGI
Biological Process GO Annotation Evidence References Source
involved in branching involved in blood vessel morphogenesis IDA
IDA: Inferred from direct assay
20406889 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15161906 MGI
involved in positive regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20406889 MGI
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of cartilage development IDA
IDA: Inferred from direct assay
19956691 MGI
involved in positive regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
20406889 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
22783020 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18997172 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18986983 MGI
NOT involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
20406889 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18997172 MGI
involved in vasculogenesis IDA
IDA: Inferred from direct assay
20406889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 2

  • bone morphogenetic protein 9

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P992008 PF-07868489 / Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05353 GDF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174781 Human ACVRL1 mRNA / Unkown
HY-RS19136 Gdf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25626 Gdf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf2 NCBI NCBI:2658