Klf5 - Kruppel-like factor 5 Gene

Also Known as CKLF; IKLF; Bteb2; 4930520J07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12224

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of transcription, DNA-templated; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (Kruppel like factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Klf5 Products (1)

mRNA Protein Name
NM_009769.4 NP_033899.2 Krueppel-like factor 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12101409 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12101409 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
27743478 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
27743478 MGI
enables MRF binding IPI
IPI: Inferred from physical interaction
27743478 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27743478 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
27743478 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12101409 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12101409 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
23266329 MGI
acts upstream of microvillus assembly IMP
IMP: Inferred from mutant phenotype
12101409 MGI
acts upstream of or within myotube differentiation involved in skeletal muscle regeneration IDA
IDA: Inferred from direct assay
27743478 MGI
acts upstream of or within myotube differentiation involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
27743478 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23266329 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12101409 MGI
acts upstream of or within positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20719859 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27743478 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
27743478 MGI
acts upstream of or within positive regulation of transcription by transcription factor localization IDA
IDA: Inferred from direct assay
27743478 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27743478 MGI
acts upstream of regulation of microvillus assembly IMP
IMP: Inferred from mutant phenotype
23266329 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23266329 MGI
acts upstream of or within satellite cell activation involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
27743478 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
acts upstream of or within skeletal muscle satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
27743478 MGI
acts upstream of or within skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
27743478 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21503901 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
27743478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Krueppel-like factor 5

  • BTE-binding protein 2

  • basic transcription element-binding protein 2

  • intestinal-enriched krueppel-like factor

  • transcription factor BTEB2

Klf5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Klf5 Q9Z0Z7 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
22307056
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19994 ML264 Inhibitor 98.32% Unkown
HY-136530 SR18662 Inhibitor 99.61% Unkown
HY-N1570 Pterosin B Inhibitor 99.98% Unkown
HY-139691 SR15006 Inhibitor 99.90% Unkown
HY-W011044 CID 5951923 Inhibitor 98.87% Unkown
HY-182820 YZ-836P Inhibitor / Unkown
HY-RS07342 KLF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162875 PROTAC BRD4 Degrader-27 / Unkown
HY-169213 LN-439A Inhibitor / Unkown
HY-RS16676 Klf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23111 Klf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klf5 NCBI NCBI:688