Tspo - translocator protein Gene

Also Known as IBP; PBR; Bzrp; Tspo1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12257

Summary

Enables transmembrane transporter binding activity. Involved in several processes, including negative regulation of Autophagy of mitochondrion; negative regulation of protein ubiquitination; and protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]

Tspo Products (1)

mRNA Protein Name
NM_009775.4 NP_033905.3 translocator protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
25470454 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment of protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
25470454 MGI
involved in maintenance of protein location in mitochondrion IMP
IMP: Inferred from mutant phenotype
25470454 MGI
involved in negative regulation of ATP metabolic process IMP
IMP: Inferred from mutant phenotype
25470454 MGI
involved in negative regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
25470454 MGI
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
25470454 MGI
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
25470454 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
25470454 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translocator protein

  • PKBS

  • benzodiazepine receptor, peripheral

  • isoquinoline-binding protein

  • mitochondrial benzodiazepine receptor

  • peripheral-type benzodiazepine receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-15527 Emapunil Inhibitor 99.94% Phase 2
HY-111191 ONO-2952 99.51% Phase 2
HY-122607 DPA-714 99.86% Phase 2
HY-19854 TRO-40303 / Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19567 PK 11195 Inhibitor 99.91% Unkown
HY-153248 PBR28 98.91% Unkown
HY-400882 Tosylate-DPA-714 Ligand 98.78% Unkown
HY-148833 MDM2-p53-IN-16 Inhibitor 99.08% Unkown
HY-150407 TSPO ligand-1 Inducer 98.0% Unkown
HY-RS15177 TSPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111191A (R)-ONO-2952 99.81% Unkown
HY-141804 ER176 99.77% Unkown
HY-150409 TSPO ligand-2 Ligand 99.63% Unkown
HY-W782122 Photoclick cholesterol 99.9% Unkown
HY-169964 TSPO/Carbonic Anhydrase Modulator 1 Modulator / Unkown
HY-147225 TSPO Ligand-Linker Conjugates 1 Activator / Unkown
HY-150410 TSPO ligand-3 / Unkown
HY-172534 BPN-01 Substrate / Unkown
HY-175340 Kv7.2/Kv7.3 activator-3 Activator / Unkown
HY-186105A (-)-P7C3-S243 Inhibitor / Unkown
HY-RS15178 TSPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W634748 Desalkylgidazepam Agonist / Unkown
HY-RS16721 Tspo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23157 Tspo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122607S DPA-714-d10 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tspo NCBI NCBI:706