Cacna1a - calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Gene

Also Known as BI; la; tg; EA2; FHM; MHP; rkr; APCA; HPCA; MHP1; SCA6; smrl; Caca1a; Cav2.1; Ccha1a; nmf352; alpha1A; Cacnl1a4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12286

Summary

Enables high voltage-gated Calcium Channel activity and voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Acts upstream of or within several processes, including cellular ion homeostasis; chemical synaptic transmission; and nervous system development. Located in dendrite and neuronal cell body. Part of voltage-gated Calcium Channel complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1a Products (4)

mRNA Protein Name
NM_001252059.1 NP_001238988.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 2
NM_001252060.1 NP_001238989.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 3
NM_001252061.1 NP_001238990.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 4
NM_007578.3 NP_031604.3 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables high voltage-gated calcium channel activity IGI
IGI: Inferred from genetic interaction
11756409 MGI
enables high voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
9742139 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1370480 MGI
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
8632762 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
9614225 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
25741235 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IMP
IMP: Inferred from mutant phenotype
25741235 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult walking behavior IGI
IGI: Inferred from genetic interaction
8719807 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
4799944 MGI
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
16890369 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
9614225 MGI
acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
10670432 MGI
acts upstream of or within calcium-ion regulated exocytosis IMP
IMP: Inferred from mutant phenotype
12065603 MGI
acts upstream of or within central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
6945603 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
1306163 MGI
acts upstream of or within cerebellar Purkinje cell layer development IMP
IMP: Inferred from mutant phenotype
1306163 MGI
acts upstream of or within cerebellar molecular layer development IMP
IMP: Inferred from mutant phenotype
7697385 MGI
acts upstream of or within cerebellum maturation IMP
IMP: Inferred from mutant phenotype
11344116 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10611370 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
10336181 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
9614225 MGI
acts upstream of or within gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
10670432 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IMP
IMP: Inferred from mutant phenotype
8565963 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
8957685 MGI
acts upstream of hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
11182254 MGI
acts upstream of or within intracellular chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
8565963 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
8158221 MGI
acts upstream of or within musculoskeletal movement, spinal reflex action IMP
IMP: Inferred from mutant phenotype
11718712 MGI
acts upstream of or within negative regulation of hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
11182254 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
4941467 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
1486501 MGI
acts upstream of or within neuromuscular process IGI
IGI: Inferred from genetic interaction
10630211 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
11344116 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
4799944 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
10686170 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
4941467 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
10899223 MGI
acts upstream of or within neuron-neuron synaptic transmission IMP
IMP: Inferred from mutant phenotype
16540584 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
8632762 MGI
acts upstream of or within receptor clustering IMP
IMP: Inferred from mutant phenotype
12624181 MGI
acts upstream of or within regulation of acetylcholine secretion, neurotransmission IMP
IMP: Inferred from mutant phenotype
10686170 MGI
acts upstream of or within regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
572084 MGI
acts upstream of or within regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
8632762 MGI
acts upstream of or within regulation of hormone levels IMP
IMP: Inferred from mutant phenotype
8229069 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
1355109 MGI
acts upstream of or within regulation of sulfur amino acid metabolic process IMP
IMP: Inferred from mutant phenotype
1485534 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
11718712 MGI
acts upstream of or within rhythmic synaptic transmission IMP
IMP: Inferred from mutant phenotype
16474392 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
17156092 MGI
acts upstream of or within synapse assembly IMP
IMP: Inferred from mutant phenotype
10336181 MGI
NOT acts upstream of or within synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
10322048 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
10322048 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
1355109 MGI
acts upstream of or within vestibular nucleus development IMP
IMP: Inferred from mutant phenotype
8719615 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
15451373 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25741235 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25741235 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15451373 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
15090043 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
15090043 MGI
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
10328888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent P/Q-type calcium channel subunit alpha-1A

  • brain calcium channel I

  • calcium channel, L type, alpha-1 polypeptide

  • leaner

  • rocker

  • tottering

  • voltage-gated calcium channel subunit alpha Cav2.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01791 CACNA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21232 Cacna1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27749 Cacna1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1a NCBI NCBI:773