Capn1 - calpain 1 Gene

Also Known as Capa1; Capa-1; mu-calpin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12333

Summary

Enables calcium-dependent cysteine-type endopeptidase activity. Acts upstream of or within mammary gland involution; proteolysis; and receptor catabolic process. Located in cytosol; lysosome; and mitochondrion. Is expressed in molar; oral region epithelium; and skin. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]

Capn1 Products (2)

mRNA Protein Name
NM_001110504.1 NP_001103974.1 calpain-1 catalytic subunit
NM_007600.3 NP_031626.1 calpain-1 catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17529984 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17529984 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mammary gland involution IMP
IMP: Inferred from mutant phenotype
22555453 MGI
acts upstream of or within proteolysis IMP
IMP: Inferred from mutant phenotype
22555453 MGI
acts upstream of or within receptor catabolic process IDA
IDA: Inferred from direct assay
17529984 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22555453 MGI
located in lysosome IDA
IDA: Inferred from direct assay
22555453 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
22555453 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-1 catalytic subunit

  • CANP 1

  • calcium-activated neutral proteinase 1

  • calpain mu-type

  • calpain-1 large subunit

  • micromolar-calpain

  • mu-calpain

  • muCANP

Recombinant Capn1 Proteins

Cat. No. Product Name Accession Purity
HY-P72114 CAPN1 Protein, Mouse (His) O35350 (M1-A713) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-RS01883 CAPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01895 CAPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17903 Capn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24372 Capn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn1 NCBI NCBI:823