Casp3 - caspase 3 Gene

Also Known as CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12367

About Casp3

Chromosome 8: 47,070,326-47,092,724 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 334 orthologues, 11 paralogues and is associated with 73 phenotypes. Broad expression in CNS E18 (RPKM 54.1), CNS E14 (RPKM 37.8) and 16 other tissues.

Summary

This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through Apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal Apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Casp3 Products (2)

mRNA Protein Name
NM_009810.3 NP_033940.1 caspase-3
NM_001284409.1 NP_001271338.1 caspase-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
15231831 MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
IMP: Inferred from mutant phenotype
12970760 MGI
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
14657025 MGI
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
16183742 MGI
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
IDA: Inferred from direct assay
12124386 MGI
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
17544522 MGI
enables endopeptidase activity IDA
IDA: Inferred from direct assay
12124386 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
12427836 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
11549719 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17124493 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
11092819 MGI
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within anterior neural tube closure IMP
IMP: Inferred from mutant phenotype
21515572 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
9512515 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
15068794 MGI
acts upstream of or within epithelial cell apoptotic process IDA
IDA: Inferred from direct assay
17901126 MGI
acts upstream of or within execution phase of apoptosis IDA
IDA: Inferred from direct assay
12124386 MGI
acts upstream of or within execution phase of apoptosis IGI
IGI: Inferred from genetic interaction
16469926 MGI
acts upstream of or within execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
11549719 MGI
involved in execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
8934524 MGI
acts upstream of or within fibroblast apoptotic process IDA
IDA: Inferred from direct assay
12847083 MGI
acts upstream of or within fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
16469926 MGI
acts upstream of or within glial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11549719 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
16469926 MGI
involved in intrinsic apoptotic signaling pathway in response to osmotic stress IDA
IDA: Inferred from direct assay
21716255 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
15068794 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
12970760 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
12427836 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10618441 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10479688 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21716255 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
15231831 MGI
involved in regulation of synaptic vesicle cycle IDA
IDA: Inferred from direct assay
33303681 MGI
involved in regulation of synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
33303681 MGI
acts upstream of or within response to UV IDA
IDA: Inferred from direct assay
11092819 MGI
acts upstream of or within response to UV IGI
IGI: Inferred from genetic interaction
16469926 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
14507967 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
11374883 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12477715 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21151119 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
21151119 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22358842 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21151119 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
21151119 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp3 Protein Structure

CASc

CASc: smart00115 (36 - 276)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

caspase-3

  • SREBP cleavage activity 1

  • apopain

  • caspase 3, apoptosis related cysteine protease

  • cysteine protease CPP32

  • protein Yama

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N10336 Notoginsenoside R4 99.90% Unkown
HY-RS01952 CASP3 Human Pre-designed siRNA Set A / Unkown
HY-10132 CASP3 activator 1 Activator / Unkown
HY-175177 XIAP-CASP7 PPI-IN-1 / Unkown
HY-177208 BW-AQ-113 / Unkown
HY-P10656 Ac-DEVDD-TPP Inducer / Unkown
HY-RS01953 Casp3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01954 Casp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp3 NCBI NCBI:836