ACKR2 - atypical chemokine receptor 2 Gene

Also Known as D6; hD6; CCR9; CCBP2; CCR10; CMKBR9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1238

About ACKR2

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,809,445-42,867,286 (from NCBI)

This gene has 11 transcripts (splice variants), 122 orthologues and 23 paralogues. Biased expression in placenta (RPKM 6.7), liver (RPKM 1.2) and 9 other tissues.

Summary

This gene encodes a beta Chemokine Receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of Chemokine Receptor genes. [provided by RefSeq, Jul 2008]

ACKR2 Products (1)

mRNA	Protein	Name
NM_001296.5	NP_001287.2	atypical chemokine receptor 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine receptor activity	IDA IDA: Inferred from direct assay	9364936	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables scavenger receptor activity	IMP IMP: Inferred from mutant phenotype	23633677	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	23633677	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23633677	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACKR2 Protein Structure

7tm_1

0
100
200
300
384 a.a.

Protein Preferred Names	Protein Names
atypical chemokine receptor 2	C-C chemokine receptor D6

ACKR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACKR2	O00590	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	ACKR2	O00590	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	ACKR2	O00590	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	ACKR2	O00590	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	ACKR2	O00590	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	ACKR2	O00590	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	ACKR2	O00590	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	ACKR2	O00590	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	ACKR2	O00590	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	ACKR2	O00590	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	ACKR2	O00590	MS4A1	Homo sapiens	P11836	Validated Y2H	32296183
Intra	ACKR2	O00590	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	ACKR2	O00590	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACKR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700378	ACKR2 Protein, Human (Cell-Free, His)	O00590 (M1-A384)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Immunodeficiency 49	IMD49 Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Immunodeficiency 49, Severe Combined Scid, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Severe Combined Immunodeficiency, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities Scid, T-Cell-Negative, B-Cell-Positive, Nk-Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Chancroid	Ulcus Molle, Skin Chancroids Bubo Due To Haemophilus Ducreyi Soft Chancre Ulcus Molle
Ileitis	Crohn'S Ileitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00161	ACKR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20849	Ackr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27363	Ackr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ACKR2	VGNC	VGNC:59510
Bos taurus	ACKR2	VGNC	VGNC:25540
Macaca mulatta	ACKR2	VGNC	VGNC:110387
Rattus norvegicus	ACKR2	RGD	RGD:620323
Canis familiaris	ACKR2	VGNC	VGNC:37508
Mus musculus	ACKR2	MGD	MGI:1891697
Others	ACKR2	NCBI