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Runx1 - runt related transcription factor 1 Gene

Also Known as AML1; Cbfa2; Pebp2a2; Pebpa2b; CBF-alpha-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12394

Summary

Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of alpha-beta T cell differentiation; regulation of gene expression; and response to retinoic acid. Acts upstream of or within several processes, including animal organ development; behavioral response to pain; and nervous system development. Located in basement membrane and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Runx1 Products (4)

mRNA	Protein	Name
NM_001111021.2	NP_001104491.1	runt-related transcription factor 1 isoform 1
NM_001111022.2	NP_001104492.1	runt-related transcription factor 1 isoform 2
NM_001111023.2	NP_001104493.1	runt-related transcription factor 1 isoform 3
NM_009821.3	NP_033951.2	runt-related transcription factor 1 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7774816	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12807883	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12551949	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17377532	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7774816	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within behavioral response to pain	IMP IMP: Inferred from mutant phenotype	16446141	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	23861879	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	16174759	MGI
acts upstream of or within definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	10207104	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	16174759	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	17011173	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16174759	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	16174759	MGI
acts upstream of or within myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	19182774	MGI
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	18258917	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17377532	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24582971	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18258917	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	16446141	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15240886	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	25834056	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	18258917	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21151104	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	10943840	MGI
acts upstream of or within positive regulation of cell maturation	IMP IMP: Inferred from mutant phenotype	24582971	MGI
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	17377532	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19090621	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	17377532	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12807883	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29924977	MGI
involved in regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	17377532	MGI
acts upstream of or within regulation of hair follicle cell proliferation	IMP IMP: Inferred from mutant phenotype	21464233	MGI
acts upstream of or within regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	21464233	MGI
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	18439490	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15389629	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in basement membrane	IDA IDA: Inferred from direct assay	17011173	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17377532	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
runt-related transcription factor 1	SL3-3 enhancer factor 1 alpha B subunit SL3/AKV core-binding factor alpha B subunit acute myeloid leukemia 1 protein core binding factor alpha 2 core-binding factor subunit alpha-2 oncogene AML-1 polyomavirus enhancer-binding protein 2 alpha B subun

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108470	Ro5-3335	Inhibitor	99.52%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Runx1	NCBI	NCBI:861