Cdh3 - cadherin 3 Gene

Also Known as Cadp; Cdhp; Pcad; P-cadherin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12560

Summary

This gene encodes a calcium-dependent cell-cell adhesion protein containing five Cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar Cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Cdh3 Products (2)

mRNA Protein Name
NM_001037809.5 NP_001032898.1 cadherin-3 isoform a preproprotein
NM_007665.3 NP_031691.1 cadherin-3 isoform b preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15148305 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
15728677 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12060406 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-3

  • RPE-specific cadherin

  • placental cadherin

Recombinant Cdh3 Proteins

Cat. No. Product Name Accession Purity
HY-P7701 Cadherin-3 Protein, Mouse (HEK293, Fc) P10287 (E100-G647) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700690 Cadherin-3 Protein, Mouse (HEK293, His) P10287 (E100-G647) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990645 PF-03732010 99.68% Phase 1
HY-P991341 FF-21101 Inhibitor 96.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W1124025 (5-Cl)-DXd / Unkown
HY-RS02325 CDH15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02336 CDH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18343 Cdh3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24822 Cdh3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991342 CQY684 Inhibitor 97.60% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh3 NCBI NCBI:1001