Cdh6 - cadherin 6 Gene

Also Known as cad6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12563

Summary

This gene encodes a member of the Cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit delay in mesenchyme-to-epithelial conversion and a loss of nephrons. Multiple distinct genes of the Cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]

Cdh6 Products (1)

mRNA Protein Name
NM_007666.4 NP_031692.2 cadherin-6 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
28957665 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
28957665 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28957665 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28957665 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12139922 MGI
is active in synapse IDA
IDA: Inferred from direct assay
28957665 MGI
is active in synapse IMP
IMP: Inferred from mutant phenotype
28957665 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-6

  • K-cadherin

  • kidney cadherin

Recombinant Cdh6 Proteins

Cat. No. Product Name Accession Purity
HY-P77037 Cadherin-6/KCAD Protein, Mouse (HEK293, His) P97326 (T19-A615) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990028 Raludotatug Inhibitor 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164734 Raludotatug Deruxtecan 99.29% Unkown
HY-RS02339 CDH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17584 Cdh6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24044 Cdh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991108 Anti-CDH6/K-Cadherin Antibody Inhibitor 95.45% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh6 NCBI NCBI:1004