Cdkn2c - cyclin dependent kinase inhibitor 2C Gene

Also Known as p18; INK4c; p18-INK6; p18INK4c; p18-INK4c

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12580

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, and contains five ankyrin repeats. This protein interacts with both CDK4 and CDK6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]

Cdkn2c Products (2)

mRNA Protein Name
NM_001301368.1 NP_001288297.1 cyclin-dependent kinase 4 inhibitor C
NM_007671.3 NP_031697.1 cyclin-dependent kinase 4 inhibitor C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
7739547 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
7739547 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7739547 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 4 inhibitor C

  • cyclin-dependent kinase 6 inhibitor

  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02417 CDKN2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18854 Cdkn2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25346 Cdkn2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn2c NCBI NCBI:1031