CDKN2C - cyclin dependent kinase inhibitor 2C Gene

Also Known as p18; INK4C; p18-INK4C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1031

About CDKN2C

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:50,968,706-50,974,634 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 72 phenotypes. Broad expression in fat (RPKM 34.6), ovary (RPKM 9.5) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2C Products (2)

mRNA	Protein	Name
NM_001262.3	NP_001253.1	cyclin-dependent kinase 4 inhibitor C
NM_078626.3	NP_523240.1	cyclin-dependent kinase 4 inhibitor C

CDKN2C Protein Structure

Ank_4

Ank_2

0
100
168 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 4 inhibitor C	CDK6 inhibitor p18

CDKN2C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDKN2C	P42773	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	CDKN2C	P42773	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	CDKN2C	P42773	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	REL	Homo sapiens	Q04864-2	Y2H Array	25910212
Intra	CDKN2C	P42773	REL	Homo sapiens	Q04864-2	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	REL	Homo sapiens	Q04864-2	Validated Y2H	25910212
Intra	CDKN2C	P42773	NAGK	Homo sapiens	Q9UJ70-2	Validated Y2H	25910212
Intra	CDKN2C	P42773	NAGK	Homo sapiens	Q9UJ70-2	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	NAGK	Homo sapiens	Q9UJ70-2	Y2H Array	25910212
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081-3	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081-3	Validated Y2H	25910212
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081-3	Y2H Array	31515488
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081-3	Y2H Array	25910212
Intra	CDKN2C	P42773	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	CDKN2C	P42773	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884-3	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884-3	Validated Y2H	25910212
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884-3	Y2H Array	25910212
Intra	CDKN2C	P42773	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	CDKN2C	P42773	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	CDKN2C	P42773	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Y2H Array	25416956
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Y2H Array	25910212
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Y2H Array	32296183
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	AHCYL1	Homo sapiens	O43865	Validated Y2H	25910212
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	Anti Bait CoIP	17353931
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	Y2H Array	31515488
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	BFG-2H	27107012
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	Anti Tag CoIP	28514442
Intra	CDKN2C	P42773	CDK4	Homo sapiens	P11802	Y2H Array	32296183
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Anti Bait CoIP	17353931
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Validated Y2H	25910212
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	BFG-2H	27107012
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Y2H Array	25910212
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Y2H Array	25416956
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	Anti Tag CoIP	25416956
Intra	CDKN2C	P42773	CDK6	Homo sapiens	Q00534	SLC	25910212
Intra	CDKN2C	P42773	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	CDKN2C	P42773	NAGK	Homo sapiens	Q9UJ70	Y2H Array	25416956
Intra	CDKN2C	P42773	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	CDKN2C	P42773	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	CDKN2C	P42773	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	CDKN2C	P42773	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	CDKN2C	P42773	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	CDKN2C	P42773	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	CDKN2C	P42773	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	CDKN2C	P42773	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	CDKN2C	P42773	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	CDKN2C	P42773	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081	Y2H Array	31515488
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081	Y2H Prey Pooling	25416956
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	CDKN2C	P42773	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
Intra	CDKN2C	P42773	NIF3L1	Homo sapiens	Q9GZT8	Y2H Bait-Prey Pool	25910212
Intra	CDKN2C	P42773	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25910212
Intra	CDKN2C	P42773	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25910212
Intra	CDKN2C	P42773	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CDKN2C	P42773	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	CDKN2C	P42773	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	CTDSP1	Homo sapiens	Q9GZU7	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	CTDSP1	Homo sapiens	Q9GZU7	Validated Y2H	32296183
Intra	CDKN2C	P42773	CTDSP1	Homo sapiens	Q9GZU7	Y2H Array	32296183
Intra	CDKN2C	P42773	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	CDKN2C	P42773	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	CDKN2C	P42773	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	CDKN2C	P42773	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDKN2C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70034	CDKN2C Protein, Human (His)	P42773 (M1-Q168)	≥ 95%, as determined by reducing SDS-PAGE.

CDKN2C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81003	CDKN2C Antibody (YA3497)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Anaplastic Oligodendroglioma
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Multiple Endocrine Neoplasia, Type Iv	Multiple Endocrine Neoplasia Type 4 MEN4 Multiple Endocrine Neoplasia 4 Neoplasia, Endocrine, Multiple, Type Iv
Water-Clear Cell Adenoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02417	CDKN2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18854	Cdkn2c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25346	Cdkn2c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDKN2C	VGNC	VGNC:107506
Macaca mulatta	CDKN2C	VGNC	VGNC:97747
Rattus norvegicus	CDKN2C	RGD	RGD:2325
Mus musculus	CDKN2C	MGD	MGI:105388
Bos taurus	CDKN2C	VGNC	VGNC:27146
Canis familiaris	CDKN2C	VGNC	VGNC:39072
Others	CDKN2C	NCBI