TMIGD2 - transmembrane and immunoglobulin domain containing 2 Gene

Also Known as CD28H; IGPR1; IGPR-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126259

About TMIGD2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,292,227-4,302,389 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.5) and 14 other tissues.

Summary

Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TMIGD2 Products (4)

mRNA Protein Name
NM_001169126.2 NP_001162597.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 2 precursor
NM_001308232.2 NP_001295161.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 3
NM_001395549.1 NP_001382478.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 4 precursor
NM_144615.3 NP_653216.2 transmembrane and immunoglobulin domain-containing protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
23784006 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23784006 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
23784006 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: Inferred from direct assay
23784006 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
22419821 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
23784006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMIGD2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (30 - 115)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

transmembrane and immunoglobulin domain-containing protein 2

  • CD28 homolog

Recombinant TMIGD2 Proteins

Cat. No. Product Name Accession Purity
HY-P71370 TMIGD2 Protein, Human (HEK293, His) Q96BF3-1 (L23-G150) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77249 TMIGD2 Protein, Human (HEK293, Fc) Q96BF3-1/NP_653216.2 (L23-G150) ≥ 95%, as determined by reducing SDS-PAGE.

TMIGD2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810059 TMIGD2 Antibody (YA9403) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14757 TMIGD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown