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Ccr1 - chemokine (C-C motif) receptor 1 Gene

Also Known as Cmkbr1; Mip-1a-R

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12768

About Ccr1

Chromosome 9: 123,762,161-123,768,729 reverse strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 151 orthologues, 25 paralogues and is associated with 44 phenotypes. Broad expression in liver E18 (RPKM 2.5), large intestine adult (RPKM 2.2) and 23 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Involved in negative regulation of innate immune response. Acts upstream of or within inflammatory response; leukocyte chemotaxis; and myeloid cell differentiation. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including dorsal aorta; extraembryonic component; limb; liver; and urogenital ridge. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ccr1 Products (1)

mRNA	Protein	Name
NM_009912.4	NP_034042.3	C-C chemokine receptor type 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	7594543	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7594543	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	9166425	MGI
acts upstream of or within leukocyte chemotaxis	IDA IDA: Inferred from direct assay	7594543	MGI
acts upstream of or within leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	9166425	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	9166425	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	15557190	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr1 Protein Structure

7tmA_CCR1

0
100
200
300
355 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 1	C-C CKR-1 CC-CKR-1 CCR-1 MIP-1 alpha R MIP-1 alphaR MIP-1alpha-R RANTES-R chemokine (C-C) receptor 1 macrophage inflammatory protein 1-alpha receptor

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15545	AZD-4818		99.10%	Phase 2
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	98.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12080	BX471	Antagonist	99.98%	Unkown
HY-18611A	Abaucin	Antagonist	99.59%	Unkown
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	Unkown
HY-18611	Abaucin hydrochloride	Antagonist	99.94%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-P4191A	Met-RANTES (human) acetate	Antagonist	99.39%	Unkown
HY-15546	BMS-817399	Antagonist	99.66%	Unkown
HY-124759	CCR1 antagonist 9	Antagonist	99.65%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-12079	CP-481715	Antagonist	/	Unkown
HY-124668	CCR1 antagonist 12	Antagonist	/	Unkown
HY-124668A	CCR1 antagonist 13	Antagonist	/	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown
HY-185661	IBS007125	Inhibitor	/	Unkown
HY-171476	CP-865569	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr1	NCBI	NCBI:1230