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Ccr7 - chemokine (C-C motif) receptor 7 Gene

Also Known as EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12775

About Ccr7

Chromosome 11: 99,035,022-99,045,903 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 197 orthologues, 25 paralogues and is associated with 48 phenotypes. Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 7.1) and 2 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Acts upstream of or within chemotaxis; homeostasis of number of cells; and immune response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and white fat. Used to study Sjogren's syndrome. Orthologous to human CCR7 (C-C motif Chemokine Receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Ccr7 Products (2)

mRNA	Protein	Name
NM_001301713.1	NP_001288642.1	C-C chemokine receptor type 7 isoform b
NM_007719.2	NP_031745.2	C-C chemokine receptor type 7 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-C chemokine receptor activity	IMP IMP: Inferred from mutant phenotype	10520991	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22922463	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within chemotaxis	IMP IMP: Inferred from mutant phenotype	10520991	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	24069263	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	10520991	MGI
involved in mature conventional dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	15845453	MGI
acts upstream of negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	20176793	MGI
involved in negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	17785582	MGI
involved in positive regulation of T cell costimulation	IMP IMP: Inferred from mutant phenotype	15845453	MGI
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17785582	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	10520991	MGI
involved in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	IMP IMP: Inferred from mutant phenotype	15845453	MGI
involved in positive regulation of humoral immune response	IMP IMP: Inferred from mutant phenotype	10520991	MGI
involved in positive regulation of hypersensitivity	IMP IMP: Inferred from mutant phenotype	10520991	MGI
involved in positive regulation of immunological synapse formation	IMP IMP: Inferred from mutant phenotype	15845453	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	15845453	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	21051556	MGI
involved in regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	20176793	MGI
involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	20176793	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	20638137	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	23620790	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19008373	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21051556	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr7 Protein Structure

7tm_GPCRs

0
100
200
300
378 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 7	EBV-induced G-protein coupled receptor 1 MIP-3 beta receptor chemokine (C-C) receptor 7 epstein-Barr virus-induced G-protein coupled receptor 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112701	CCR6 inhibitor 1	Inhibitor	99.60%	Unkown
HY-133073	CCR7 Ligand 1	Antagonist	99.19%	Unkown
HY-120427	Cosalane	Antagonist	99.78%	Unkown
HY-N10116A	Calamenene	Activator	/	Unkown
HY-173052	SLW131	Antagonist	/	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr7	NCBI	NCBI:1236