Cnr1 - cannabinoid receptor 1 (brain) Gene

Also Known as CB1; CB-R; CB1A; CB1B; CB1R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12801

About Cnr1

Chromosome 4: 33,924,593-33,948,831 forward strand.GRCm39:CM000997.3

This gene has 3 transcripts (splice variants), 206 orthologues, 18 paralogues and is associated with 83 phenotypes. Biased expression in cerebellum adult (RPKM 24.), CNS E18 (RPKM 17.4) and 7 other tissues.

Summary

Enables Cannabinoid Receptor activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in several cellular components, including GABA-ergic synapse; growth cone; and presynaptic membrane. Is integral component of mitochondrial membrane and integral component of presynaptic membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnr1 Products (4)

mRNA Protein Name
NM_007726.5 NP_031752.1 cannabinoid receptor 1
NM_001355021.2 NP_001341950.1 cannabinoid receptor 1
NM_001355020.2 NP_001341949.1 cannabinoid receptor 1
NM_001365881.1 NP_001352810.1 cannabinoid receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cannabinoid receptor activity IMP
IMP: Inferred from mutant phenotype
27826249 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
20962221 MGI
acts upstream of or within glucose homeostasis IPI
IPI: Inferred from physical interaction
23954414 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11516401 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
11516401 MGI
involved in retrograde trans-synaptic signaling by endocannabinoid IDA
IDA: Inferred from direct assay
11516401 MGI
involved in retrograde trans-synaptic signaling by endocannabinoid IMP
IMP: Inferred from mutant phenotype
11516401 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
11516401 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
11516401 MGI
located in axon IDA
IDA: Inferred from direct assay
20962221 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11516401 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11516401 MGI
located in growth cone IDA
IDA: Inferred from direct assay
20962221 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
27826249 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
27828947 MGI
is active in presynaptic membrane IMP
IMP: Inferred from mutant phenotype
27828947 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cnr1 Protein Structure

7tmA_CB1

7tmA_CB1: cd15340 (117 - 408)

7tmA_CB1

7tmA_CB1: cd15340 (118 - 144)

7tmA_CB1

7tmA_CB1: cd15340 (152 - 177)

7tmA_CB1

7tmA_CB1: cd15340 (189 - 219)

7tmA_CB1

7tmA_CB1: cd15340 (231 - 251)

7tmA_CB1

7tmA_CB1: cd15340 (271 - 300)

7tmA_CB1

7tmA_CB1: cd15340 (336 - 366)

7tmA_CB1

7tmA_CB1: cd15340 (376 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

cannabinoid receptor 1

  • brain-type cannabinoid receptor

  • striatal cannabinoid receptor type 1 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153169 6PPD-Q Inhibitor 99.77% Unkown
HY-N5074 Terrestrosin D 99.30% Unkown
HY-RS02914 CNR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02915 Cnr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02916 Cnr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10135 PCDHA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnr1 NCBI NCBI:1268