Smc3 - structural maintenance of chromosomes 3 Gene

Also Known as HCAP; SmcD; Cspg6; Mmip1; SMC-3; Bamacan

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13006

Summary

Enables chromatin binding activity and mediator complex binding activity. Acts upstream of or within meiotic cell cycle and stem cell population maintenance. Located in lateral element. Part of nuclear meiotic cohesin complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Apr 2022]

Smc3 Products (1)

mRNA Protein Name
NM_007790.3 NP_031816.2 structural maintenance of chromosomes protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
20720539 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28636939 MGI
enables mediator complex binding IDA
IDA: Inferred from direct assay
20720539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10375619 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within meiotic cell cycle IPI
IPI: Inferred from physical interaction
12759374 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
Cellular Component GO Annotation Evidence References Source
part of cohesin complex IDA
IDA: Inferred from direct assay
10375619 MGI
located in lateral element IDA
IDA: Inferred from direct assay
15870106 MGI
part of meiotic cohesin complex IDA
IDA: Inferred from direct assay
21527826 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10375619 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 3

  • SMC protein 3

  • basement membrane-associated chondroitin proteoglycan

  • chondroitin sulfate proteoglycan 6

  • chromosome segregation protein SmcD

  • mad member-interacting protein 1

  • structural maintenace of chromosomes 3

Smc3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Smc3 Q9CW03 Mecp2 Mus musculus Q9Z2D6
Anti Bait CoIP
20159591
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150772 Tubulin/HDAC-IN-1 / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-181024 PROTAC HDAC8 Degrader-4 Degrader / Unkown
HY-181979 HDAC8-IN-15 / Unkown
HY-182035 HDAC8-IN-16 / Unkown
HY-RS13419 SMC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18370 Smc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24849 Smc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc3 NCBI NCBI:9126