Cybb - cytochrome b-245, beta polypeptide Gene

Also Known as Cgd; Cyd; Nox2; gp91-1; gp91phox; CGD91-phox

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13058

About Cybb

Chromosome X: 9,301,491-9,354,010 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 210 orthologues, 5 paralogues and is associated with 59 phenotypes. Biased expression in liver E18 (RPKM 7.), spleen adult (RPKM 4.7) and 13 other tissues.

Summary

This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of Reactive Oxygen Species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Cybb Products (1)

mRNA Protein Name
NM_007807.5 NP_031833.3 cytochrome b-245 heavy chain

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21551061 MGI
enables superoxide-generating NAD(P)H oxidase activity IDA
IDA: Inferred from direct assay
22493499 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
15258578 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24739962 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
28351984 MGI
involved in superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
24739962 MGI
Cellular Component GO Annotation Evidence References Source
part of NADPH oxidase complex IDA
IDA: Inferred from direct assay
24739962 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15499027 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
23303671 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15499027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cybb Protein Structure

Ferric_reduct

Ferric_reduct: pfam01794 (64 - 219)

PLN02844

PLN02844: cl33578 (164 - 422)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (296 - 569)

NAD_binding_6

NAD_binding_6: pfam08030 (400 - 549)

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  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

cytochrome b-245 heavy chain

  • NADPH oxidase 2

  • cytochrome b558 subunit beta

  • heme-binding membrane glycoprotein gp91phox

  • neutrophil cytochrome b 91 kDa polypeptide

  • p22 phagocyte B-cytochrome

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149035 PAA4 / Unkown
HY-RS03423 CYBB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03424 Cybb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03425 Cybb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cybb NCBI NCBI:1536