Dab2 - disabled 2, mitogen-responsive phosphoprotein Gene

Also Known as p96; Doc2; Doc-2; D15Wsu122e; 5730435J12Rik; D630005B22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13132

Summary

Enables several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including endocytosis; hemopoiesis; and negative regulation of extrinsic apoptotic signaling pathway. Located in apical plasma membrane; cytoplasm; and nucleus. Part of clathrin coat of coated pit. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dab2 Products (5)

mRNA Protein Name
NM_001008702.2 NP_001008702.1 disabled homolog 2 isoform b
NM_001037905.3 NP_001032994.1 disabled homolog 2 isoform b
NM_001102400.1 NP_001095870.1 disabled homolog 2 isoform c
NM_001310446.1 NP_001297375.1 disabled homolog 2 isoform d
NM_023118.5 NP_075607.2 disabled homolog 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
12234931 MGI
enables cargo receptor activity IDA
IDA: Inferred from direct assay
16984970 MGI
enables clathrin adaptor activity IDA
IDA: Inferred from direct assay
16984970 MGI
enables clathrin binding IDA
IDA: Inferred from direct assay
12234931 MGI
enables integrin binding IMP
IMP: Inferred from mutant phenotype
15734730 MGI
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
12234931 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
12826668 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9569023 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
12413896 MGI
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
15734730 MGI
involved in clathrin coat assembly IDA
IDA: Inferred from direct assay
12234931 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15734730 MGI
acts upstream of or within hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
29925839 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
12413896 MGI
involved in myeloid cell differentiation IEP
IEP: Inferred from expression pattern
11823414 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15734730 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15734730 MGI
involved in negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
19581412 MGI
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
15894542 MGI
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
11823414 MGI
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
15734730 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15894542 MGI
involved in positive regulation of clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
16984970 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
15734730 MGI
involved in positive regulation of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15734730 MGI
involved in positive regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
23354168 MGI
involved in positive regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
20881059 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
11823414 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15734730 MGI
involved in positive regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15894542 MGI
acts upstream of or within receptor-mediated endocytosis IPI
IPI: Inferred from physical interaction
12413896 MGI
acts upstream of or within renal protein absorption IMP
IMP: Inferred from mutant phenotype
11927540 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21146513 MGI
part of clathrin coat of coated pit IDA
IDA: Inferred from direct assay
11247302 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21146513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disabled homolog 2

  • adaptor molecule disabled-2

  • differentially expressed in ovarian carcinoma 2

  • mitogen-responsive phosphoprotein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03511 DAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112114 DTPA-DAB2 / Unkown
HY-RS03512 DAB2IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20265 Dab2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26773 Dab2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dab2 NCBI NCBI:1601