Dcx - doublecortin Gene

Also Known as Dbct

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13193

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Dcx Products (7)

mRNA Protein Name
NM_001110222.1 NP_001103692.1 neuronal migration protein doublecortin isoform a
NM_001110223.1 NP_001103693.1 neuronal migration protein doublecortin isoform a
NM_001110224.1 NP_001103694.1 neuronal migration protein doublecortin isoform b
NM_001410009.1 NP_001396938.1 neuronal migration protein doublecortin isoform b
NM_001410010.1 NP_001396939.1 neuronal migration protein doublecortin isoform d
NM_001410011.1 NP_001396940.1 neuronal migration protein doublecortin isoform e
NM_010025.2 NP_034155.2 neuronal migration protein doublecortin isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14550532 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IGI
IGI: Inferred from genetic interaction
16387638 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
16387638 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IGI
IGI: Inferred from genetic interaction
16387638 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
16387638 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
19342486 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
19342486 MGI
acts upstream of or within layer formation in cerebral cortex IMP
IMP: Inferred from mutant phenotype
19342486 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
16387638 MGI
acts upstream of or within pyramidal neuron development IGI
IGI: Inferred from genetic interaction
19342486 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
29788228 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
29788228 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23447615 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29788228 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
29788228 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
23861879 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal migration protein doublecortin

  • doublecortex

  • doublin

  • lis-X

  • lissencephalin-X

  • lissencephaly, X-linked (doublecortin)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117787 TUG-905 Agonist / Unkown
HY-RS03601 DCX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17791 Dcx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24259 Dcx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dcx NCBI NCBI:1641