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Drd5 - dopamine receptor D5 Gene

Also Known as D5R; Drd-5; Drd1b; Gpcr1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13492

About Drd5

Chromosome 5: 38,476,710-38,479,861 forward strand.GRCm39:CM000998.3

This gene has 1 transcript (splice variant), 190 orthologues, 32 paralogues and is associated with 12 phenotypes.

Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gs. Acts upstream of or within several processes, including learning; long-term synaptic depression; and regulation of blood pressure. Located in brush border membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (Dopamine Receptor D5). [provided by Alliance of Genome Resources, Apr 2022]

Drd5 Products (1)

mRNA	Protein	Name
NM_013503.4	NP_038531.1	D(1B) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA IDA: Inferred from direct assay	16962565	MGI
enables dopamine neurotransmitter receptor activity, coupled via Gs	IMP IMP: Inferred from mutant phenotype	13679419	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15598876	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	15696326	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	13679419	MGI
acts upstream of or within mating behavior	IMP IMP: Inferred from mutant phenotype	15696326	MGI
acts upstream of or within negative regulation of blood pressure	IGI IGI: Inferred from genetic interaction	12486173	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	12486173	MGI
acts upstream of or within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	12486173	MGI
acts upstream of or within regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	15696326	MGI
acts upstream of or within regulation of systemic arterial blood pressure by vasopressin	IGI IGI: Inferred from genetic interaction	12486173	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	11823893	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	12768268	MGI
acts upstream of or within sensitization	IGI IGI: Inferred from genetic interaction	11823893	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	12867509	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	11595429	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in brush border membrane	IDA IDA: Inferred from direct assay	15598876	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd5 Protein Structure

7tm_GPCRs

0
100
200
300
400
478 a.a.

Protein Preferred Names	Protein Names
D(1B) dopamine receptor	d(5) dopamine receptor dopamine D5 receptor dopamine receptor 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04006	DRD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04007	Drd5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04008	Drd5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd5	NCBI	NCBI:1816