2. Gene
  3. Esr1 - estrogen receptor 1 (alpha) Gene

Esr1 - estrogen receptor 1 (alpha) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha

Gene ID: 13982 | Gene type: protein coding

About Esr1

Chromosome 10: 4,561,593-4,955,614 forward strand.GRCm39:CM001003.3

This gene has 10 transcripts (splice variants), 212 orthologues, 8 paralogues and is associated with 197 phenotypes. Biased expression in ovary adult (RPKM 13.9), subcutaneous fat pad adult (RPKM 12.1) and 7 other tissues.

Summary

This gene encodes an Estrogen Receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast Cancer, endometrial Cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Esr1 Products(4)

mRNA Protein Name
NM_007956.5 NP_031982.1 estrogen receptor isoform 1
NM_001302533.1 NP_001289462.1 estrogen receptor isoform 2
NM_001302532.1 NP_001289461.1 estrogen receptor isoform 1
NM_001302531.1 NP_001289460.1 estrogen receptor isoform 1

Esr1 Protein Structure

Oest_recep

Oest_recep: pfam02159 (41 - 184)

NR_DBD_ER

NR_DBD_ER: cd07171 (183 - 264)

NR_LBD_ER

NR_LBD_ER: cd06949 (313 - 550)

ESR1_C

ESR1_C: pfam12743 (555 - 598)

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  • 599 a.a.
Protein Preferred Names Protein Names

estrogen receptor

C-terminally-truncated estrogen receptor alpha product-4

C-terminally-truncated estrogen receptor alpha product-5

C-terminally-truncated estrogen receptor alpha product-6

C-terminally-truncated estrogen receptor alpha product-7

estradiol receptor

nuclear receptor subfamily 3 group A member 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136255 Camizestrant Inhibitor 98.04% Phase 3
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-149480 ERD-3111 Degrader / Unkown
HY-RS04529 ESR1 Human Pre-designed siRNA Set A / Unkown
HY-RS04530 Esr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04531 Esr1 Rat Pre-designed siRNA Set A / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr1 NCBI NCBI:2099