SUN5 - Sad1 and UNC84 domain containing 5 Gene

Also Known as SPAG4L; SPGF16; TSARG4; dJ726C3.1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 140732

About SUN5

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,983,775-33,004,433 (from NCBI)

This gene has 4 transcripts (splice variants), 137 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 7.9).

Summary

The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]

SUN5 Products (1)

mRNA Protein Name
NM_080675.4 NP_542406.2 SUN domain-containing protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
12621555 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
27640305 GOA
located in sperm head-tail coupling apparatus IDA
IDA: Inferred from direct assay
27640305 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUN5 Protein Structure

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (232 - 362)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
Protein Preferred Names Protein Names

SUN domain-containing protein 5

  • epididymis secretory sperm binding protein

SUN5 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
SUN5 Q8TC36 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Spermatogenic Failure 16

  • SPGF16

  • Acephalic Spermatozoa Syndrome

  • Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

  • Acephalic Spermatozoa Syndrome
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Infertility
Spermatogenic Failure 14

  • SPGF14
Spermatogenic Failure 15

  • SPGF15

  • Spermatogenic Failure, 15
Oligoasthenoteratozoospermia

  • Oat

  • Oligoasthenoteratospermia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14032 SUN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus SUN5 RGD RGD:1306357
Canis familiaris SUN5 VGNC VGNC:46987
Bos taurus SUN5 VGNC VGNC:35476
Felis catus SUN5 VGNC VGNC:65844
Mus musculus SUN5 MGD MGI:1923657
Macaca mulatta SUN5 VGNC VGNC:78133
Others SUN5 NCBI