UBE2F - ubiquitin conjugating enzyme E2 F (putative) Gene

Also Known as NCE2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140739

About UBE2F

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,967,014-238,042,782 (from NCBI)

This gene has 23 transcripts (splice variants), 234 orthologues and 24 paralogues. Ubiquitous expression in bone marrow (RPKM 11.8), thyroid (RPKM 10.6) and 25 other tissues.

Summary

Enables NEDD8 conjugating enzyme activity. Involved in protein neddylation. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBE2F Products (5)

mRNA Protein Name
NM_001278305.2 NP_001265234.1 NEDD8-conjugating enzyme UBE2F isoform 1
NM_001278306.2 NP_001265235.1 NEDD8-conjugating enzyme UBE2F isoform 2
NM_001278307.2 NP_001265236.1 NEDD8-conjugating enzyme UBE2F isoform 3
NM_001278308.2 NP_001265237.1 NEDD8-conjugating enzyme UBE2F isoform 4
NM_080678.3 NP_542409.1 NEDD8-conjugating enzyme UBE2F isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NEDD8 conjugating enzyme activity IDA
IDA: Inferred from direct assay
19250909 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19250909 GOA
Biological Process GO Annotation Evidence References Source
involved in protein neddylation IDA
IDA: Inferred from direct assay
19250909 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2F Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (37 - 179)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

NEDD8-conjugating enzyme UBE2F

  • NEDD8 carrier protein UBE2F

UBE2F Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2F Q969M7 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
UBE2F Q969M7 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
UBE2F Q969M7 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Intra
UBE2F Q969M7 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2F Q969M7 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
UBE2F Q969M7 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
UBE2F Q969M7 PAX6 Homo sapiens P26367
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2F Proteins

Cat. No. Product Name Accession Purity
HY-P79452 UBE2N/Ubc13 Protein, Human (sf9, His, StrepII) P61088 (A2-I152) ≥ 90%, as determined by reducing SDS-PAGE.

UBE2F Antibodies

Cat. No. Product Name Application Reactivity
HY-P83546 NCE2 Antibody (YA3291) WB, IHC-P, ICC/IF, FC Human
HY-P83546A NCE2 Antibody (YA3291)(PBS only) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Brachydactyly, Type E2

  • Brachydactyly Type E2

  • BDE2

  • Brachydactyly E2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160799 HA-9104 Inducer 98.54% Unkown
HY-RS15345 UBE2F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20507 Ube2f Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27015 Ube2f Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2F VGNC VGNC:55693
Rattus norvegicus UBE2F RGD RGD:1307608
Felis catus UBE2F VGNC VGNC:80398
Mus musculus UBE2F MGD MGI:1915171
Canis familiaris UBE2F VGNC VGNC:59099
Macaca mulatta UBE2F VGNC VGNC:104562
Others UBE2F NCBI