Fli1 - Friend leukemia integration 1 Gene

Also Known as Sic1; EWSR2; Fli-1; SIC-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14247

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Used to study systemic scleroderma. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Fli1 Products (3)

mRNA Protein Name
NM_001410251.1 NP_001397180.1 Friend leukemia integration 1 transcription factor isoform 2
NM_001410252.1 NP_001397181.1 Friend leukemia integration 1 transcription factor isoform 3
NM_008026.6 NP_032052.1 Friend leukemia integration 1 transcription factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17606295 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17606295 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16757682 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21867929 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10981960 MGI
acts upstream of or within blood circulation IMP
IMP: Inferred from mutant phenotype
10981960 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
16757682 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17606295 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10981960 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
12527908 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Friend leukemia integration 1 transcription factor

  • retroviral integration site protein Fli-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-122903 TK216 Inhibitor 99.65% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-14507 YK-4-279 99.91% Unkown
HY-173364 EB-TCIP Inducer 99.58% Unkown
HY-RS04977 FLI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122903S TK216-d4 98.52% Unkown
HY-163325 Fli-1-IN-1 fumarate Inhibitor / Unkown
HY-163325A Fli-1-IN-1 Inhibitor / Unkown
HY-RS04978 FLII Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174685 Human FLI1 mRNA / Unkown
HY-RS18357 Fli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24836 Fli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fli1 NCBI NCBI:2313