FLI1 - Fli-1 proto-oncogene, ETS transcription factor Gene

Also Known as EWSR2; FLI-1; SIC-1; BDPLT21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2313

About FLI1

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:128,685,351-128,813,267 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues, 28 paralogues and is associated with 102 phenotypes. Broad expression in spleen (RPKM 33.9), lymph node (RPKM 17.6) and 20 other tissues.

Summary

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

FLI1 Products (4)

mRNA	Protein	Name
NM_001167681.3	NP_001161153.1	Friend leukemia integration 1 transcription factor isoform 2
NM_001271010.2	NP_001257939.1	Friend leukemia integration 1 transcription factor isoform 3
NM_001271012.2	NP_001257941.1	Friend leukemia integration 1 transcription factor isoform 4
NM_002017.5	NP_002008.2	Friend leukemia integration 1 transcription factor isoform 1

FLI1 Protein Structure

SAM_PNT

Ets

0
100
200
300
400
452 a.a.

Protein Preferred Names	Protein Names
Friend leukemia integration 1 transcription factor	Ewing sarcoma breakpoint region 2

FLI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FLI1	Q01543	SMAD3	Homo sapiens	P84022	Y2H Array	20211142
Intra	FLI1	Q01543	SOX30	Homo sapiens	O94993	Y2H Array	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

FLI1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83092	FLI1 Antibody (YA2837)	WB, IHC-P	Human, Rat
HY-P83092A	FLI1 Antibody (YA2837)(PBS only)	WB, IHC-P	Human, Rat
HY-P84459	FLI1 Antibody (YA4156)	IHC-P, FC, ELISA	Human
HY-P84459A	FLI1 Antibody (YA4156)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85955	FLI1 Antibody (YA5647)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 21	BDPLT21
Isolated Delta-Storage Pool Disease	Isolated Delta-Spd Isolated Dense-Spd Isolated Dense-Storage Pool Disease
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Jacobsen Syndrome	Chromosome 11q Deletion Syndrome Partial 11q Monosomy Syndrome Jacobsen Distal 11q Deletion Syndrome JBS 11q Partial Monosomy Syndrome Chromosome 11q Deletion 11q Deletion 11q Monosomy Deletion 11q Monosomy 11q Partial Monosomy 11q 11q Deletion Disorder 11q Deletion Syndrome 11q Terminal Deletion Disorder 11q- Deletion Syndrome 11q23 Deletion Disorder Jacobsen Thrombocytopenia 11q Terminal Deletion Syndrome Del(11)(Q23.3) Del(11)(Qter) Distal Deletion 11q Distal Monosomy 11q Monosomy 11qter Telomeric Deletion 11q Paris-Trousseau Thrombocytopenia
Thrombocytopenia, Paris-Trousseau Type	Paris-Trousseau Thrombocytopenia TCPT Paris-Trousseau Syndrome Thrombocytopenia Paris-Trousseau Type Chromosome 11q23 Deletion Syndrome Jacobsen Distal 11q Deletion Syndrome
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Hemangioendothelioma
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
Erythroleukemia
Angiosarcoma	Hemangiosarcoma
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Ewing Sarcoma Of Bone	Ewing'S Sarcoma Of Bone Bone Ewing Sarcoma Bone Ewing'S Sarcoma Bone Localized Ewing Sarcoma Bone Localized Ewing'S Sarcoma Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor Localized Skeletal Ewing'S Sarcoma Localized Bone Ewing Sarcoma
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Intracranial Primitive Neuroectodermal Tumor	Intracranial Pnet Intracranial Primitive Neuroectodermal Neoplasm
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Hemangioma	Hemangiomas
Askin'S Tumor	Askin Tumor Askin Tumour Askin'S Tumour
Malignant Epithelioid Hemangioendothelioma	Epithelioid Hemangioendothelioma, Malignant
Malignant Hemangioma
Small Cell Osteogenic Sarcoma	Small Cell Osteosarcoma Round Cell Osteosarcoma Osteosarcoma Small Cell
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Hobnail Hemangioma
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Intravascular Fasciitis	Intravascular Pseudosarcomatous Fasciitis
Rhabdomyosarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122903	TK216	Inhibitor	99.65%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14507	YK-4-279		99.91%	Unkown
HY-173364	EB-TCIP	Inducer	99.58%	Unkown
HY-RS04977	FLI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122903S	TK216-d4		98.52%	Unkown
HY-163325	Fli-1-IN-1 fumarate	Inhibitor	/	Unkown
HY-163325A	Fli-1-IN-1	Inhibitor	/	Unkown
HY-RS04978	FLII Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174685	Human FLI1 mRNA		/	Unkown
HY-RS18357	Fli1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24836	Fli1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FLI1	VGNC	VGNC:72669
Felis catus	FLI1	VGNC	VGNC:102888
Mus musculus	FLI1	MGD	MGI:95554
Rattus norvegicus	FLI1	RGD	RGD:1309837
Canis familiaris	FLI1	VGNC	VGNC:40898
Bos taurus	FLI1	VGNC	VGNC:29031
Others	FLI1	NCBI