Gad2 - glutamic acid decarboxylase 2 Gene

Also Known as GAD65; Gad-2; GAD(65); 6330404F12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14417

Summary

Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in glutamate decarboxylation to succinate. Predicted to act upstream of or within neurotransmitter biosynthetic process. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Gad2 Products (1)

mRNA Protein Name
NM_008078.2 NP_032104.2 glutamate decarboxylase 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15479642 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23500099 MGI
located in synapse IDA
IDA: Inferred from direct assay
15479642 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate decarboxylase 2

  • 65 kDa glutamic acid decarboxylase

  • GAD-65

Recombinant Gad2 Proteins

Cat. No. Product Name Accession Purity
HY-P75177 GAD2/GAD65 Protein, Mouse (sf9, His-GST) Q548L4 (M1-L585) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75178 GAD2/GAD65 Protein, Mouse (sf9) Q548L4 (N-G&P, M1-L585) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05228 GAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18758 Gad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25245 Gad2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gad2 NCBI NCBI:2572