GAD2 - glutamate decarboxylase 2 Gene

Also Known as GAD65

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2572

About GAD2

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:26,216,372-26,304,558 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 7.7).

Summary

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

GAD2 Products (2)

mRNA	Protein	Name
NM_000818.3	NP_000809.1	glutamate decarboxylase 2
NM_001134366.2	NP_001127838.1	glutamate decarboxylase 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10671565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAD2 Protein Structure

Pyridoxal_deC

0
100
200
300
400
500
585 a.a.

Protein Preferred Names	Protein Names
glutamate decarboxylase 2	65 kDa glutamic acid decarboxylase

GAD2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GAD2	Q05329	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	GAD2	Q05329	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	GAD2	Q05329	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	GAD2	Q05329	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	GAD2	Q05329	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	MEST	Homo sapiens	Q5EB52	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	MEST	Homo sapiens	Q5EB52	Validated Y2H	32296183
Intra	GAD2	Q05329	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	GAD2	Q05329	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	GAD2	Q05329	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	GAD2	Q05329	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	GAD2	Q05329	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	GAD2	Q05329	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	GAD2	Q05329	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	GAD2	Q05329	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	GAD2	Q05329	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	GAD2	Q05329	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	GAD2	Q05329	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	GAD2	Q05329	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	GAD2	Q05329	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	FAM163A	Homo sapiens	Q96GL9	Y2H Array	32296183
Intra	GAD2	Q05329	FAM163A	Homo sapiens	Q96GL9	Validated Y2H	32296183
Intra	GAD2	Q05329	FAM163A	Homo sapiens	Q96GL9	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	RDH10	Homo sapiens	Q8IZV5	Y2H Array	32296183
Intra	GAD2	Q05329	RDH10	Homo sapiens	Q8IZV5	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	RDH10	Homo sapiens	Q8IZV5	Validated Y2H	32296183
Intra	GAD2	Q05329	SYCE2	Homo sapiens	Q6PIF2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SYCE2	Homo sapiens	Q6PIF2	Y2H Array	32296183
Intra	GAD2	Q05329	SYCE2	Homo sapiens	Q6PIF2	Validated Y2H	32296183
Intra	GAD2	Q05329	TSPAN33	Homo sapiens	Q86UF1	Validated Y2H	32296183
Intra	GAD2	Q05329	HIGD1C	Homo sapiens	A8MV81	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	HIGD1C	Homo sapiens	A8MV81	Y2H Array	32296183
Intra	GAD2	Q05329	SMPD2	Homo sapiens	O60906	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SMPD2	Homo sapiens	O60906	Y2H Array	32296183
Intra	GAD2	Q05329	DERL3	Homo sapiens	Q96Q80	Y2H Array	32296183
Intra	GAD2	Q05329	DERL3	Homo sapiens	Q96Q80	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	DERL3	Homo sapiens	Q96Q80	Validated Y2H	32296183
Intra	GAD2	Q05329	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	GAD2	Q05329	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	GAD2	Q05329	CYB561D1	Homo sapiens	Q8N8Q1	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	CYB561D1	Homo sapiens	Q8N8Q1	Validated Y2H	32296183
Intra	GAD2	Q05329	CYB561D1	Homo sapiens	Q8N8Q1	Y2H Array	32296183
Intra	GAD2	Q05329	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	GAD2	Q05329	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	GAD2	Q05329	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	APOC4	Homo sapiens	P55056	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	APOC4	Homo sapiens	P55056	Y2H Array	32296183
Intra	GAD2	Q05329	RHEX	Homo sapiens	Q6ZWK4	Validated Y2H	32296183
Intra	GAD2	Q05329	RHEX	Homo sapiens	Q6ZWK4	Y2H Array	32296183
Intra	GAD2	Q05329	RHEX	Homo sapiens	Q6ZWK4	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	GAD2	Q05329	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956
Intra	GAD2	Q05329	ABHD5	Homo sapiens	Q8WTS1	Validated Y2H	32296183
Intra	GAD2	Q05329	ABHD5	Homo sapiens	Q8WTS1	Y2H Array	32296183
Intra	GAD2	Q05329	ABHD5	Homo sapiens	Q8WTS1	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	GAD2	Q05329	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	GAD2	Q05329	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Array	32296183
Intra	GAD2	Q05329	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	ARMC12	Homo sapiens	Q5T9G4-2	Validated Y2H	32296183
Intra	GAD2	Q05329	SDR16C5	Homo sapiens	Q8N3Y7	Validated Y2H	32296183
Intra	GAD2	Q05329	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Array	32296183
Intra	GAD2	Q05329	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	FADS6	Homo sapiens	Q8N9I5	Validated Y2H	32296183
Intra	GAD2	Q05329	FADS6	Homo sapiens	Q8N9I5	Y2H Array	32296183
Intra	GAD2	Q05329	FADS6	Homo sapiens	Q8N9I5	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	DERL1	Homo sapiens	Q9BUN8	Validated Y2H	32296183
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Y2H Prey Pooling	25416956
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Validated Y2H	25416956
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Validated Y2H	32296183
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Y2H Array	25416956
Intra	GAD2	Q05329	LDAF1	Homo sapiens	Q96B96	Y2H Array	32296183
Intra	GAD2	Q05329	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	GAD2	Q05329	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	32296183
Intra	GAD2	Q05329	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	GAD2	Q05329	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	GAD2	Q05329	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	GAD2	Q05329	PBX3	Homo sapiens	Q96AL5	Y2H Array	32296183
Intra	GAD2	Q05329	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	GAD2	Q05329	PBX3	Homo sapiens	Q96AL5	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	GAD2	Q05329	DMKN	Homo sapiens	Q6E0U4	Validated Y2H	32296183
Intra	GAD2	Q05329	DMKN	Homo sapiens	Q6E0U4	Y2H Array	32296183
Intra	GAD2	Q05329	DMKN	Homo sapiens	Q6E0U4	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	GAD2	Q05329	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	GAD2	Q05329	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	GAD2	Q05329	MAL2	Homo sapiens	Q969L2	Validated Y2H	25416956
Intra	GAD2	Q05329	MAL2	Homo sapiens	Q969L2	Validated Y2H	32296183
Intra	GAD2	Q05329	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	GAD2	Q05329	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183
Intra	GAD2	Q05329	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183
Intra	GAD2	Q05329	CACNG1	Homo sapiens	Q06432	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GAD2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P75179	GAD2/GAD65 Protein, Human (sf9, GST)	Q05329/NP_000809.1 (M1-L585)	≥ 90%, as determined by reducing SDS-PAGE.

GAD2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80682	GAD65 Antibody (YA758)	WB	Human, Rat
HY-P80682A	GAD65 Antibody (YA758)(PBS only)	WB	Human, Rat

関連疾患

Diseases	Alias
Autoimmune Polyendocrine Syndrome, Type Ii	Schmidt Syndrome Autoimmune Polyendocrine Syndrome Type 2 APS2 Autoimmune Polyglandular Syndrome Type 2 Diabetes Mellitus, Addison Disease, Myxedema Polyglandular Autoimmune Syndrome, Type Ii Pga Ii Polyendocrine Autoimmune Syndrome, Type Ii Aps Ii Autoimmune Polyglandular Syndrome Type Ii Diabetes Mellitus, Addison'S Disease, Myxedema Multiple Endocrine Deficiency Syndrome, Type 2 Pga 2 Pga-Ii Polyglandular Autoimmune Syndrome, Type 2 Polyglandular Deficiency Syndrome Type 2 Schmidt'S Syndrome Autoimmune Polyendocrinopathy Type 2 Aps Type 2 Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome Autoimmune Syndrome Type Ii Polyglandular Autoimmune Syndrome Type Ii, Polyglandular
Stiff-Person Syndrome	SPS Stiff-Man Syndrome Stiff Man Syndrome Stiff Person Syndrome Moersch-Woltman Syndrome Sms Stiff-Trunk Syndrome Morsch Woltman Syndrome Stiff Person Syndrome And Related Disorders Stiff Person Spectrum Disorder Classic Stiff Person Syndrome Classic Sps Focal Stiff Limb Syndrome Focal Stiff-Person Syndrome Stiff Leg Syndrome Progressive Encephalomyelitis With Rigidity
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetes Mellitus, Ketosis-Prone	Diabetic Ketoacidosis KPD Diabetes Mellitus, Ketosis-Prone, Susceptibility To Ketosis-Prone Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetic Ketoacidosis Nos Dka - [Diabetic Ketoacidosis] Nos Dka - [Diabetic Ketoacidosis] Without Coma Dka - [Diabetic Ketoacidosis] With Coma
Limbic Encephalitis
Type 1 Diabetes Mellitus 5	Diabetes Mellitus, Insulin-Dependent, 5 Latent Autoimmune Diabetes In Adults IDDM5 Insulin-Dependent Diabetes Mellitus 5 T1D5 Lada Type 1.5 Diabetes Diabetes Mellitus, Insulin-Dependent, Type 5
Autoimmune Epilepsy
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Diabetes Mellitus	Diabetes
Type 1 Diabetes Mellitus 15	Diabetes Mellitus, Insulin-Dependent, 15 Iddm15 Insulin-Dependent Diabetes Mellitus 15 T1D15 Insulin-Dependent Diabetes Mellitus-15
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Somatization Disorder	Somatoform Disorders Briquet'S Disorder Polysomatising Disorder Somatisation Disorder Somatoform Disorder
Generalized Anxiety Disorder	Anxiety Generalized
Fourth Cranial Nerve Palsy	Fourth Nerve Palsy Fourth Cranial Nerve Paresis Fourth Or Trochlear Nerve Palsy 4th Nerve Palsy Fourth Cranial Nerve Paralysis Superior Oblique Palsy Trochlear Nerve Palsy Trochlear Nerve Paralysis Trochlear Nerve Weakness Isolated Trochlear Nerve Palsy Atrophy Of Fourth Cranial Nerve Atrophy Of Trochlear Nerve
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Autoimmune Disease Of Endocrine System
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Pernicious Anemia	Anemia, Pernicious Anemia Pernicious Pernicious Anaemia Addison'S Anaemia Biermer'S Anaemia Biermer'S Anemia Acquired Pernicious Anemia Addison-Biermer Anemia Addisonian Anemia Biermer Anemia Biermer'S Disease Juvenile Onset Pernicious Anemia Biermer Disease Biermer-Addison Disease
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia	APS1 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Apeced Pga I Hypoadrenocorticism With Hypoparathyroidism And Superficial Moniliasis Autoimmune Polyendocrinopathy Syndrome , Type I, With Or Without Reversible Metaphyseal Dysplasia Polyglandular Autoimmune Syndrome, Type 1 Autoimmune Polyglandular Syndrome Type 1 Autoimmune Polyendocrine Syndrome Type 1 Autoimmune Polyendocrinopathy Syndrome Type 1 Whitaker Syndrome Aps Type 1 Polyglandular Type I Autoimmune Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome Aps I Autoimmune Polyglandular Syndrome, Type I Polyglandular Autoimmune Syndrome, Type I Aps 1 Autoimmune Polyglandular Syndrome Type I Pga 1 Pga-I Polyglandular Autoimmune Syndrome Type 1 Type I Polyglandular Autoimmune Syndrome Aire Deficiency Autoimmune Polyendocrinopathy With Candidiasis And Ectodermal Dystrophy Autoimmune Polyglandular Syndrome, Type 1 Autoimmune Polyendocrinopathy Type 1 Apeced Syndrome Autoimmune Hypoparathyroidism-Chronic Candidiasis-Addison Disease Syndrome Ham Syndrome Hypoparathyroidism-Addison Disease-Mucocutaneous Candidiasis Syndrome Medac Syndrome Multiple Endocrine Deficiency-Addison Disease-Candidiasis Syndrome Autoimmune Polyendocrine Syndrome 1, With Or Without Reversible Metaphyseal Dysplasia Aps-1 Autoimmune Polyendocrine Syndrome Type I Autoimmune Polyendocrinopathy Syndrome Type I Autosomal Dominant Autoimmune Polyendocrinopathy Syndrome Type I Polyglandular Autoimmune Syndrome Type I Polyglandular Deficiency Syndrome Persian-Jewish Type Autoimmune Polyendocrinopathy Syndrome, Type I, Autosomal Dominant Polyendocrinopathy Autoimmune, Type 1, With/Without Reversible Metaphyseal Dysplasia
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Movement Disease	Movement Disorders Movement Disorder
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Mutism
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Adjustment Disorder	Adjustment Reaction Adjustment Disorders Adjustment Disease Brief Situational Non-Psychotic Disorder Adaptation Reaction Nos Emotional Crisis Situational Disorder Situational Disturbance Situational Maladjustment Situational Reaction Situational Reaction With Maladjustment Transient Situational Disturbance
Retinitis Pigmentosa 84	RP84 Retinitis Pigmentosa, Type 84
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Polyradiculopathy
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Anterograde Amnesia	Amnesia, Anterograde
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Autoimmune Disease Of Peripheral Nervous System
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Adrenal Cortical Hypofunction	Adrenal Cortical Insufficiency Corticoadrenal Insufficiency
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Type 1 Diabetes Mellitus 12	Diabetes Mellitus, Insulin-Dependent, 12 IDDM12 Insulin-Dependent Diabetes Mellitus 12 T1D12 Type 1 Diabetes Mellitus 12, Susceptibility To Diabetes Mellitus, Insulin-Dependent, Type 12
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Gummatous Syphilis
Speech Disorder	Speech Disorders
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Choreatic Disease	Chorea Hereditary Chorea
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Meningovascular Neurosyphilis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05228	GAD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18758	Gad2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25245	Gad2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	GAD2	VGNC	VGNC:29205
Felis catus	GAD2	VGNC	VGNC:62431
Canis familiaris	GAD2	VGNC	VGNC:41068
Mus musculus	GAD2	MGD	MGI:95634
Rattus norvegicus	GAD2	RGD	RGD:2653
Macaca mulatta	GAD2	VGNC	VGNC:72863
Others	GAD2	NCBI