Glud1 - glutamate dehydrogenase 1 Gene

Also Known as Glud; Gdh-X; Gludl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14661

Summary

Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of Insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Glud1 Products (1)

mRNA Protein Name
NM_008133.4 NP_032159.1 glutamate dehydrogenase 1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
20670938 MGI
enables glutamate dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11792727 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16959573 MGI
Biological Process GO Annotation Evidence References Source
involved in glutamine metabolic process IMP
IMP: Inferred from mutant phenotype
23663782 MGI
acts upstream of or within positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
16959573 MGI
involved in tricarboxylic acid metabolic process IMP
IMP: Inferred from mutant phenotype
23663782 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17923681 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16959573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate dehydrogenase 1, mitochondrial

  • GDH 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13653 (-)-Epigallocatechin Gallate Inducer 99.75% Phase 4
HY-150526 EGCG-4″-sulfate Inducer / Phase 4

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103096 R162 Inhibitor 99.89% Unkown
HY-13653R (-)-Epigallocatechin Gallate (Standard) Inducer 98.05% Unkown
HY-13653S1 (-)-Epigallocatechin Gallate-d4 Inducer 97.14% Unkown
HY-RS05507 GLUD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05795 GRID1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170017S (−)-Epigallocatechin Gallate-d3/d4 Inducer / Unkown
HY-RS17659 Glud1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24120 Glud1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glud1 NCBI NCBI:2746