Slc6a9 - solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Gene

Also Known as Glyt1; Glyt-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14664

About Slc6a9

Chromosome 4: 117,691,703-117,732,395 forward strand.GRCm39:CM000997.3

This gene has 12 transcripts (splice variants), 206 orthologues, 20 paralogues and is associated with 25 phenotypes. Ubiquitous expression in liver E14.5 (RPKM 33.4), cerebellum adult (RPKM 3.9) and 27 other tissues.

Summary

Enables glycine transmembrane transporter activity. Involved in glycine import across plasma membrane; neurotransmitter uptake; and positive regulation of cellular biosynthetic process. Acts upstream of or within glycine secretion, neurotransmission. Located in plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Used to study glycine encephalopathy. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a9 Products (4)

mRNA	Protein	Name
NM_001355175.2	NP_001342104.1	sodium- and chloride-dependent glycine transporter 1 isoform 2
NM_001369017.1	NP_001355946.1	sodium- and chloride-dependent glycine transporter 1 isoform 3 precursor
NM_001369016.1	NP_001355945.1	sodium- and chloride-dependent glycine transporter 1 isoform 1
NM_008135.4	NP_032161.2	sodium- and chloride-dependent glycine transporter 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycine transmembrane transporter activity	IDA IDA: Inferred from direct assay	1618338	MGI
enables glycine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15159536	MGI
enables glycine:sodium symporter activity	IDA IDA: Inferred from direct assay	1618338	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in glycine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	28495915	MGI
acts upstream of or within glycine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	22988142	MGI
acts upstream of or within glycine transport	IDA IDA: Inferred from direct assay	1618338	MGI
involved in glycine transport	IMP IMP: Inferred from mutant phenotype	14622582	MGI
acts upstream of negative regulation of NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	15159536	MGI
involved in neurotransmitter uptake	IDA IDA: Inferred from direct assay	1618338	MGI
involved in neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	1618338	MGI
involved in positive regulation of heme biosynthetic process	IMP IMP: Inferred from mutant phenotype	28495915	MGI
involved in positive regulation of hemoglobin biosynthetic process	IMP IMP: Inferred from mutant phenotype	28495915	MGI
involved in regulation of synaptic transmission, glycinergic	IMP IMP: Inferred from mutant phenotype	14622582	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17724084	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a9 Protein Structure

SLC6sbd_GlyT1

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633 a.a.

Protein Preferred Names	Protein Names
sodium- and chloride-dependent glycine transporter 1	glycine transporter 1 solute carrier family 6 member 9

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13320	SLC6A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13321	Slc6a9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13322	Slc6a9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a9	NCBI	NCBI:6536