Got1 - glutamic-oxaloacetic transaminase 1, soluble Gene

Also Known as cCAT; Got-1; cAspAT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14718

Summary

Enables L-aspartate:2-oxoglutarate aminotransferase activity and phosphatidylserine decarboxylase activity. Acts upstream of or within several processes, including dicarboxylic acid metabolic process; fatty acid homeostasis; and glycerol biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 Products (1)

mRNA Protein Name
NM_010324.2 NP_034454.2 aspartate aminotransferase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
1914521 MGI
enables phosphatidylserine decarboxylase activity IDA
IDA: Inferred from direct assay
3242498 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within aspartate biosynthetic process IDA
IDA: Inferred from direct assay
4193185 MGI
acts upstream of or within fatty acid homeostasis IDA
IDA: Inferred from direct assay
17545671 MGI
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
17545671 MGI
acts upstream of or within glutamate catabolic process to aspartate IDA
IDA: Inferred from direct assay
4193185 MGI
acts upstream of or within glycerol biosynthetic process IDA
IDA: Inferred from direct assay
17545671 MGI
involved in malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
37813964 MGI
acts upstream of or within oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
4193185 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
4193185 MGI
located in cytosol IDA
IDA: Inferred from direct assay
4193185 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartate aminotransferase, cytoplasmic

  • cysteine aminotransferase, cytoplasmic

  • cysteine transaminase, cytoplasmic

  • cytosolic aspartate aminotransferase

  • glutamate oxaloacetate transaminase 1, soluble

  • transaminase A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0091 Adapalene 99.94% Yes
HY-B0091R Adapalene (Standard) / Unkown
HY-B0091A Adapalene sodium salt 99.69% Yes

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160818 MC3138 Activator 99.92% Unkown
HY-122723 GOT1 inhibitor-1 Inhibitor 98.75% Unkown
HY-124825 iGOT1-01 Inhibitor 99.18% Unkown
HY-N3307 (+)-Medioresinol 99.13% Unkown
HY-RS05605 GOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N6237 Aspulvinone O ≥96.0% Unkown
HY-B0091S Adapalene-d3 / Unkown
HY-RS05596 GOLT1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W752012 Adapalene-13C6 / Unkown
HY-N14093 Aspulvinone H / Unkown
HY-RS16967 Got1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23410 Got1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Got1 NCBI NCBI:2805