DTX3L - deltex E3 ubiquitin ligase 3L Gene

Also Known as BBAP; RNF143

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151636

About DTX3L

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,564,338-122,575,203 (from NCBI)

This gene has 2 transcripts (splice variants), 355 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 14.2), spleen (RPKM 13.2) and 25 other tissues.

Summary

DTX3L functions as an E3 ubiquitin Ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3L Products (1)

mRNA	Protein	Name
NM_138287.3	NP_612144.1	E3 ubiquitin-protein ligase DTX3L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables STAT family protein binding	IPI IPI: Inferred from physical interaction	26479788	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	28525742	GOA
enables enzyme inhibitor activity	IMP IMP: Inferred from mutant phenotype	24790097	GOA
enables histone H4K91 ubiquitin ligase activity	IDA IDA: Inferred from direct assay	19818714	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19818714	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26479788	GOA
enables histone ubiquitin ligase activity	IMP IMP: Inferred from mutant phenotype	26479788	GOA
enables protein ADP-ribosyltransferase-substrate adaptor activity	IDA IDA: Inferred from direct assay	28525742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16809771	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	24790097	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19818714	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	23230272	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28525742	GOA
involved in DNA repair-dependent chromatin remodeling	IMP IMP: Inferred from mutant phenotype	19818714	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	23230272	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	24790097	GOA
involved in negative regulation of ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	24790097	GOA
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of chromatin binding	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of defense response to virus by host	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	26479788	GOA
involved in positive regulation of protein localization to early endosome	IMP IMP: Inferred from mutant phenotype	24790097	GOA
involved in positive regulation of protein localization to nucleus	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of receptor catabolic process	IMP IMP: Inferred from mutant phenotype	24790097	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	26479788	GOA
involved in protein autoubiquitination	IMP IMP: Inferred from mutant phenotype	24790097	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26479788	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16809771	GOA
colocalizes with early endosome	IDA IDA: Inferred from direct assay	24790097	GOA
located in lysosome	IDA IDA: Inferred from direct assay	24790097	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	26479788	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16809771	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24790097	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTX3L Protein Structure

zf-RING_2

0
200
400
600
740 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase DTX3L	B-lymphoma- and BAL-associated protein

DTX3L Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04041	DTX3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19429	Dtx3l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25920	Dtx3l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DTX3L	RGD	RGD:1565144
Macaca mulatta	DTX3L	VGNC	VGNC:71995
Felis catus	DTX3L	VGNC	VGNC:61651
Canis familiaris	DTX3L	VGNC	VGNC:40118
Mus musculus	DTX3L	MGD	MGI:2656973
Bos taurus	DTX3L	VGNC	VGNC:28239
Others	DTX3L	NCBI