Ptpn6 - protein tyrosine phosphatase, non-receptor type 6 Gene

Also Known as me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15170

Summary

Enables several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine Phosphatase activity. Involved in epididymis development; negative regulation of interleukin-6 production; and negative regulation of tumor necrosis factor production. Acts upstream of or within several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Located in cell-cell junction. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including central nervous system; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine Phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn6 Products (2)

mRNA Protein Name
NM_001077705.2 NP_001071173.1 tyrosine-protein phosphatase non-receptor type 6 isoform b
NM_013545.3 NP_038573.2 tyrosine-protein phosphatase non-receptor type 6 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
8632004 MGI
enables SH3 domain binding IDA
IDA: Inferred from direct assay
8632004 MGI
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
19948503 MGI
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
10229828 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8632004 MGI
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
8632004 MGI
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
11745335 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
23509253 MGI
acts upstream of or within B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9254656 MGI
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9064344 MGI
involved in epididymis development IMP
IMP: Inferred from mutant phenotype
11266449 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
10229828 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
23509158 MGI
acts upstream of or within natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
6971254 MGI
acts upstream of or within negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
9254656 MGI
involved in negative regulation of inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 MGI
involved in negative regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
17954568 MGI
involved in negative regulation of mast cell activation involved in immune response IDA
IDA: Inferred from direct assay
10026201 MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
9254656 MGI
involved in negative regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
17954568 MGI
acts upstream of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
9254656 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
23509158 MGI
acts upstream of or within platelet formation IGI
IGI: Inferred from genetic interaction
23509158 MGI
acts upstream of or within positive regulation of cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
23509158 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
8632004 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
9064344 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
9254656 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IGI
IGI: Inferred from genetic interaction
23509253 MGI
Cellular Component GO Annotation Evidence References Source
part of alpha-beta T cell receptor complex IDA
IDA: Inferred from direct assay
9064344 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
27830702 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 6

  • SH2 phosphatase 1

  • hematopoietic cell protein-tyrosine phosphatase

  • motheaten

  • protein-tyrosine phosphatase 1C

Recombinant Ptpn6 Proteins

Cat. No. Product Name Accession Purity
HY-P73649 SHP-1 Protein, Mouse (sf9, His-GST) P29351-2 (A207-K597) ≥ 85%, as determined by reducing SDS-PAGE.

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpn6 NCBI NCBI:5777