Hipk1 - homeodomain interacting protein kinase 1 Gene

Also Known as Myak; 1110062K04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15257

Summary

Predicted to enable protein serine/threonine kinase activity; protein tyrosine kinase activity; and transcription corepressor activity. Involved in adherens junction assembly; camera-type eye morphogenesis; and neuron differentiation. Acts upstream of or within several processes, including anterior/posterior pattern specification; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and smoothened signaling pathway. Located in PML body; cytoplasm; and nuclear speck. Is expressed in several structures, including forebrain ventricular layer and future forebrain. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hipk1 Products (3)

mRNA	Protein	Name
NM_001301304.1	NP_001288233.1	homeodomain-interacting protein kinase 1 isoform 1
NM_001301306.1	NP_001288235.1	homeodomain-interacting protein kinase 1 isoform 2
NM_010432.2	NP_034562.2	homeodomain-interacting protein kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11034606	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adherens junction assembly	IMP IMP: Inferred from mutant phenotype	23565059	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16537918	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in iris morphogenesis	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in lens induction in camera-type eye	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16537918	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	12529400	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12529400	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	12529400	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeodomain-interacting protein kinase 1	nuclear body-associated kinase 2 protein kinase Myak

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	98.0%	Unkown
HY-125290	MU1210	Inhibitor	99.50%	Unkown
HY-177416	MU1787	Inhibitor	99.84%	Unkown
HY-RS06181	HIPK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17765	Hipk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24232	Hipk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hipk1	NCBI	NCBI:204851