AGR3 - anterior gradient 3, protein disulphide isomerase family member Gene

Also Known as AG3; AG-3; HAG3; hAG-3; BCMP11; PDIA18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 155465

About AGR3

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,854,681-16,881,983 (from NCBI)

This gene has 4 transcripts (splice variants), 104 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 65.6), colon (RPKM 63.5) and 4 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]

AGR3 Products (1)

mRNA	Protein	Name
NM_176813.5	NP_789783.1	anterior gradient protein 3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables dystroglycan binding	IDA IDA: Inferred from direct assay	12592373	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12592373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGR3 Protein Structure

Thioredoxin_7

0
100
166 a.a.

Protein Preferred Names	Protein Names
anterior gradient protein 3	anterior gradient homolog 3

AGR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGR3	Q8TD06	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	AGR3	Q8TD06	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Array	32296183
Intra	AGR3	Q8TD06	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	AGR3	Q8TD06	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	AP1B1	Homo sapiens	Q10567-3	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	AP1B1	Homo sapiens	Q10567-3	Y2H Array	32296183
Intra	AGR3	Q8TD06	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	AGR3	Q8TD06	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	AGR3	Q8TD06	CD46	Homo sapiens	P15529-3	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	CD46	Homo sapiens	P15529-3	Y2H Array	32296183
Intra	AGR3	Q8TD06	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	AGR3	Q8TD06	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	AGR3	Q8TD06	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	DESI1	Homo sapiens	Q6ICB0	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	DESI1	Homo sapiens	Q6ICB0	Y2H Array	32296183
Intra	AGR3	Q8TD06	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	AGR3	Q8TD06	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	AGR3	Q8TD06	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	AGR3	Q8TD06	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	AGR3	Q8TD06	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	AGR3	Q8TD06	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	AGR3	Q8TD06	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	AGR3	Q8TD06	ERLIN1	Homo sapiens	O75477	Y2H Prey Pooling	25416956
Intra	AGR3	Q8TD06	ERLIN1	Homo sapiens	O75477	Validated Y2H	25416956
Intra	AGR3	Q8TD06	ERLIN1	Homo sapiens	O75477	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	ERLIN1	Homo sapiens	O75477	Y2H Array	25416956
Intra	AGR3	Q8TD06	ERLIN1	Homo sapiens	O75477	Y2H Array	32296183
Intra	AGR3	Q8TD06	EDA2R	Homo sapiens	Q9HAV5	Validated Y2H	32296183
Intra	AGR3	Q8TD06	EDA2R	Homo sapiens	Q9HAV5	Y2H Array	32296183
Intra	AGR3	Q8TD06	EDA2R	Homo sapiens	Q9HAV5	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	AGR3	Q8TD06	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	AGR3	Q8TD06	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	AGR3	Q8TD06	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	AGR3	Q8TD06	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	AGR3	Q8TD06	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	AGR3	Q8TD06	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	AGR3	Q8TD06	UBQLN1	Homo sapiens	Q9UMX0	Y2H	21516116
Intra	AGR3	Q8TD06	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	AGR3	Q8TD06	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	AGR3	Q8TD06	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	AGR3	Q8TD06	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	AGR3	Q8TD06	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	AGR3	Q8TD06	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	AGR3	Q8TD06	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AGR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7466	AGR3 Protein, Human (HEK293, His)	Q8TD06 (I22-L166)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Non-Proliferative Fibrocystic Change Of The Breast	Non-Proliferative Fibrocystic Change Breast Fibrocystic Change, Non-Proliferative Type
Breast Abscess	Abscess Of Breast
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00463	AGR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18907	Agr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25398	Agr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AGR3	MGD	MGI:2685734
Bos taurus	AGR3	VGNC	VGNC:25741
Macaca mulatta	AGR3	VGNC	VGNC:69685
Rattus norvegicus	AGR3	RGD	RGD:1565406
Others	AGR3	NCBI