Htr2b - 5-hydroxytryptamine (serotonin) receptor 2B Gene

Also Known as 5-HT2B; 5-HT-2B; 5-HT-2F

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15559

Summary

Enables G protein-coupled serotonin receptor activity; GTPase activator activity; and serotonin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to temperature stimulus; and protein kinase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within heart development. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; reproductive system; and sensory organ. Used to study hypertrophic cardiomyopathy. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Apr 2022]

Htr2b Products (1)

mRNA	Protein	Name
NM_008311.3	NP_032337.2	5-hydroxytryptamine receptor 2B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	17325130	MGI
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	8621713	MGI
enables serotonin binding	IDA IDA: Inferred from direct assay	17325130	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	8621713	MGI
involved in cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	19023134	MGI
involved in embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	9165122	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10944220	MGI
involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	9165122	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9165122	MGI
involved in neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	9165122	MGI
involved in neural crest cell migration	IMP IMP: Inferred from mutant phenotype	9165122	MGI
involved in phospholipase C-activating serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17325130	MGI
involved in positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	8621713	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19023134	MGI
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19308295	MGI
involved in regulation of behavior	IMP IMP: Inferred from mutant phenotype	21179162	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of G protein-coupled serotonin receptor complex	IDA IDA: Inferred from direct assay	17325130	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17325130	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17325130	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 2B	NP75 protein serotonin receptor 2B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169229	GM-60186	Inhibitor	99.34%	Unkown
HY-RS06468	HTR2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19011	Htr2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25500	Htr2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr2b	NCBI	NCBI:3357