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Idua - iduronidase, alpha-L Gene

Also Known as 6030426D08

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15932

Summary

Enables L-iduronidase activity. Acts upstream of or within several processes, including glycosaminoglycan catabolic process; learning or memory; and skeletal system development. Located in extracellular space. Used to study mucopolysaccharidosis I and otitis media. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase). [provided by Alliance of Genome Resources, Apr 2022]

Idua Products (2)

mRNA	Protein	Name
NM_008325.4	NP_032351.2	alpha-L-iduronidase isoform 1 precursor
NM_172997.1	NP_766585.1	alpha-L-iduronidase isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-iduronidase activity	IDA IDA: Inferred from direct assay	7698753	MGI
enables L-iduronidase activity	IMP IMP: Inferred from mutant phenotype	15979918	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	22580166	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	22580166	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	19751987	MGI
acts upstream of or within cartilage homeostasis	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	9097952	MGI
acts upstream of or within chemical homeostasis	IMP IMP: Inferred from mutant phenotype	9097952	MGI
acts upstream of or within dermatan sulfate catabolic process	IDA IDA: Inferred from direct assay	19751987	MGI
acts upstream of or within dermatan sulfate catabolic process	IMP IMP: Inferred from mutant phenotype	19751987	MGI
involved in dermatan sulfate catabolic process	IMP IMP: Inferred from mutant phenotype	19751987	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	25410057	MGI
acts upstream of or within glycosaminoglycan catabolic process	IDA IDA: Inferred from direct assay	16979922	MGI
acts upstream of or within glycosaminoglycan catabolic process	IMP IMP: Inferred from mutant phenotype	16979922	MGI
involved in heparan sulfate proteoglycan catabolic process	IMP IMP: Inferred from mutant phenotype	15979918	MGI
acts upstream of or within heparin catabolic process	IDA IDA: Inferred from direct assay	19751987	MGI
acts upstream of or within heparin catabolic process	IMP IMP: Inferred from mutant phenotype	19751987	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9097952	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	18022143	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	9097952	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	18022143	MGI
acts upstream of or within negative regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within negative regulation of secretion of lysosomal enzymes	IDA IDA: Inferred from direct assay	16979922	MGI
acts upstream of or within negative regulation of secretion of lysosomal enzymes	IMP IMP: Inferred from mutant phenotype	16979922	MGI
acts upstream of or within positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within positive regulation of collagen catabolic process	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	9097952	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	18022143	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16979922	MGI
is active in lysosomal lumen	IMP IMP: Inferred from mutant phenotype	9660052	MGI
is active in lysosome	IMP IMP: Inferred from mutant phenotype	19751987	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-L-iduronidase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99530	Valanafusp alfa		98.42%	Phase 2
HY-P99694	Lepunafusp alfa	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W654272	4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium		98.77%	Unkown
HY-RS06546	IDUA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17959	Idua Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24430	Idua Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Idua	NCBI	NCBI:3425