Ifnar2 - interferon (alpha and beta) receptor 2 Gene

Also Known as Ifnar-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15976

About Ifnar2

Chromosome 16: 91,169,671-91,202,477 forward strand.GRCm39:CM001009.3

This gene has 5 transcripts (splice variants), 303 orthologues, 11 paralogues and is associated with 17 phenotypes. Ubiquitous expression in adrenal adult (RPKM 31.7), lung adult (RPKM 17.) and 27 other tissues.

Summary

Enables type I interferon receptor activity. Acts upstream of or within cell population proliferation and regulation of transcription by RNA polymerase II. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and nervous system. Human ortholog(s) of this gene implicated in hepatitis B and immunodeficiency 45. Orthologous to human IFNAR2 (interferon alpha and beta receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar2 Products (3)

mRNA Protein Name
NM_001347258.1 NP_001334187.1 interferon alpha/beta receptor 2 isoform c precursor
NM_001110498.1 NP_001103968.1 interferon alpha/beta receptor 2 isoform b precursor
NM_010509.2 NP_034639.2 interferon alpha/beta receptor 2 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables type I interferon receptor activity IDA
IDA: Inferred from direct assay
9295335 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within immature T cell proliferation in thymus IDA
IDA: Inferred from direct assay
11154225 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9322767 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11154225 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ifnar2 Protein Structure

FN3

FN3: cl21522 (15 - 106)

Interfer-bind

Interfer-bind: pfam09294 (131 - 227)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

interferon alpha/beta receptor 2

  • IFN-R-2

  • IFN-alpha/beta receptor 2

  • interferon receptor 2a'

  • interferon receptor 2c

  • type I interferon alpha/beta receptor 2a

  • type I interferon receptor 2

Recombinant Ifnar2 Proteins

Cat. No. Product Name Accession Purity
HY-P78772 IFN-alpha/beta R2 Protein, Mouse (HEK293, His) O35664-1 (S22-A242) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1758 IFN-α Receptor Recognition Peptide 1 Modulator / Unkown
HY-P1758A IFN-α Receptor Recognition Peptide 1 acetate Modulator 99.29% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifnar2 NCBI NCBI:3455