IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

Also Known as IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3455

About IFNAR2

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,229,938-33,265,664 (from NCBI)

This gene has 14 transcripts (splice variants), 303 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 13.0), appendix (RPKM 12.7) and 24 other tissues.

Summary

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

IFNAR2 Products (8)

mRNA	Protein	Name
NM_000874.5	NP_000865.2	interferon alpha/beta receptor 2 isoform b
NM_001385055.1	NP_001371984.1	interferon alpha/beta receptor 2 isoform e
NM_001385054.1	NP_001371983.1	interferon alpha/beta receptor 2 isoform d
NM_001289128.2	NP_001276057.1	interferon alpha/beta receptor 2 isoform c
NM_207584.3	NP_997467.1	interferon alpha/beta receptor 2 isoform b
NM_207585.3	NP_997468.1	interferon alpha/beta receptor 2 isoform a
NM_001289125.3	NP_001276054.1	interferon alpha/beta receptor 2 isoform a
NM_001289126.2	NP_001276055.1	interferon alpha/beta receptor 2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IPI IPI: Inferred from physical interaction	8798579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7665574	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	7759950	GOA
enables type I interferon binding	IPI IPI: Inferred from physical interaction	7759950	GOA
enables type I interferon receptor activity	IDA IDA: Inferred from direct assay	7665574	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7759950	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	7759950	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	26424569	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	7759950	GOA
involved in response to interferon-alpha	IMP IMP: Inferred from mutant phenotype	26424569	GOA
involved in response to interferon-beta	IDA IDA: Inferred from direct assay	7759950	GOA
involved in response to interferon-beta	IMP IMP: Inferred from mutant phenotype	26424569	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	7665574	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26424569	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7759950	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7759950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNAR2 Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
400
515 a.a.

Protein Preferred Names	Protein Names
interferon alpha/beta receptor 2	IFN-R-2 IFN-alpha/beta receptor 2 IFNalpha/beta receptor subunit 2 human interferon alpha/beta receptor interferon (alpha, beta and omega) receptor 2 interferon alpha binding protein interferon receptor interferon-alpha/beta receptor beta chain type I interferon receptor 2

IFNAR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFNAR2	P48551	STAT1	Homo sapiens	P42224	Pull Down	9121453
Intra	IFNAR2	P48551	JAK1	Homo sapiens	P23458	Anti Tag CoIP	16710296
Intra	IFNAR2	P48551	JAK1	Homo sapiens	P23458	Pull Down	16710296
Intra	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Pull Down	9121453
Intra	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Anti Bait CoIP	17923090
Intra	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Anti Tag CoIP	17923090
Intra	IFNAR2	P48551	RACK1	Homo sapiens	P63244	Y2H	11046044
Intra	IFNAR2	P48551	RACK1	Homo sapiens	P63244	Pull Down	11046044
Intra	IFNAR2	P48551	USP18	Homo sapiens	Q9UMW8	Anti Tag CoIP	16710296
Intra	IFNAR2	P48551	IFNA2	Homo sapiens	P01563	X-Ray Diffraction	21854986
Intra	IFNAR2	P48551	IRF9	Homo sapiens	Q00978	Anti Bait CoIP	17923090
Intra	IFNAR2	P48551	IRF9	Homo sapiens	Q00978	Far-WB	17923090
Intra	IFNAR2	P48551	PDLIM1	Homo sapiens	O00151	Anti Tag CoIP	33961781
Intra	IFNAR2	P48551	CREBBP	Homo sapiens	Q92793	Anti Tag CoIP	17923090
Intra	IFNAR2	P48551	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	17923090

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNAR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72613	IFN-alpha/beta R2 Protein, Human (HEK293, His)	P48551-1 (I27-K243)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74860	IFN-alpha/beta R2 Protein, Human (HEK293, hFc)	P48551-1 (I27-K243)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74861	IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His)	P48551-1 (I27-K243)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74862A	IFN-alpha/beta R2 Protein, Human (HEK293, His, solution)	P48551-1 (I27-K243)	≥ 95%, as determined by reducing SDS-PAGE.

IFNAR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811166	IFNAR2 Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P89824	IFNAR2 Antibody (YA9168)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Torch Syndrome
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Immunodeficiency 45	IMD45
Rubella	German Measles Three Day Measles Rubella Nos
Immunodeficiency 44	IMD44
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Herpangina	Vesicular Pharyngitis
Immunodeficiency 39	IMD39 Immunodeficiency, Type 39
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection	Primary Immunodeficiency With Post-Mmr Vaccine Viral Infection
Measles	Rubeola Morbilli Measles Nos Koplik Spots

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1758	IFN-α Receptor Recognition Peptide 1	Modulator	/	Unkown
HY-P1758A	IFN-α Receptor Recognition Peptide 1 acetate	Modulator	99.29%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IFNAR2	VGNC	VGNC:30055
Rattus norvegicus	IFNAR2	RGD	RGD:1583177
Macaca mulatta	IFNAR2	VGNC	VGNC:81330
Felis catus	IFNAR2	VGNC	VGNC:103734
Mus musculus	IFNAR2	MGD	MGI:1098243
Others	IFNAR2	NCBI