Ighg1 - immunoglobulin heavy constant gamma 1 (G1m marker) Gene

Also Known as IgG1; Igh-4; VH7183

Species: Mus musculus

Gene Type: other
Gene ID: 16017

Summary

Enables antigen binding activity and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Located in external side of plasma membrane and extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables antigen binding IDA
IDA: Inferred from direct assay
4098598 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IGI
IGI: Inferred from genetic interaction
28923960 MGI
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
28923960 MGI
acts upstream of or within antibacterial humoral response IDA
IDA: Inferred from direct assay
9834074 MGI
acts upstream of or within antibody-dependent cellular cytotoxicity IDA
IDA: Inferred from direct assay
9743367 MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin IDA
IDA: Inferred from direct assay
8041705 MGI
acts upstream of or within immunoglobulin mediated immune response IDA
IDA: Inferred from direct assay
4098598 MGI
involved in immunoglobulin production IMP
IMP: Inferred from mutant phenotype
28923960 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: Inferred from direct assay
8769481 MGI
acts upstream of or within phagocytosis, recognition IDA
IDA: Inferred from direct assay
8769481 MGI
acts upstream of or within positive regulation of immune response IDA
IDA: Inferred from direct assay
10395649 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
8769481 MGI
acts upstream of or within positive regulation of type I hypersensitivity IDA
IDA: Inferred from direct assay
8552190 MGI
acts upstream of or within positive regulation of type IIa hypersensitivity IDA
IDA: Inferred from direct assay
9834201 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
28923960 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18762567 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
9707605 MGI
part of immunoglobulin complex, circulating IDA
IDA: Inferred from direct assay
4098598 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Recombinant Ighg1 Proteins

Cat. No. Product Name Accession Purity
HY-P73901 IgG1 Protein, Mouse (HEK293, C102S) P01868-1 (V98-K324, C102S) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99844 Davoceticept 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16348 IGHG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25153 Ighg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ighg1 NCBI NCBI:3500