Il10rb - interleukin 10 receptor, beta Gene

Also Known as Crfb4; CRF2-4; Il10r2; D21S58h; IL-10R2; D16H21S58; 6620401D04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16155

Summary

Enables interleukin-10 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within defense response to virus. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis B and Inflammatory Bowel Disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Il10rb Products (5)

mRNA Protein Name
NM_001405058.1 NP_001391987.1 interleukin-10 receptor subunit beta isoform 2
NM_001405059.1 NP_001391988.1 interleukin-10 receptor subunit beta isoform 3 precursor
NM_001405060.1 NP_001391989.1 interleukin-10 receptor subunit beta isoform 4
NM_001405062.1 NP_001391991.1 interleukin-10 receptor subunit beta isoform 5 precursor
NM_008349.6 NP_032375.2 interleukin-10 receptor subunit beta isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables interleukin-10 receptor activity IMP
IMP: Inferred from mutant phenotype
9463407 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11416224 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-10 receptor subunit beta

  • IL-10 receptor subunit beta

  • IL-10R subunit 2

  • IL-10R subunit beta

  • IL-10RB

  • cytokine receptor class-II member 4

  • cytokine receptor family 2 member 4

  • cytokine receptor family II, member 4

  • interleukin 10 receptor 2

  • interleukin-10 receptor subunit 2

Recombinant Il10rb Proteins

Cat. No. Product Name Accession Purity
HY-P74837 IL-10R beta Protein, Mouse (HEK293, His) Q8VHM7 (M22-S222) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74838 IL-10R beta Protein, Mouse (HEK293, hFc) Q8VHM7 (M22-S222) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06674 IL10RB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174657 Human IFNLR1 mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990776 Vimekofusp / Unkown
HY-P992038 Anti-IL-10RB Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il10rb NCBI NCBI:3588