2. Gene
  3. IL10RB - interleukin 10 receptor subunit beta Gene

IL10RB - interleukin 10 receptor subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB

Gene ID: 3588 | Gene type: protein coding

About IL10RB

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,266,367-33,297,221 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

IL10RB Products(4)

mRNA Protein Name
NM_000628.5 NP_000619.3 interleukin-10 receptor subunit beta isoform 1 precursor
NM_001405849.1 NP_001392778.1 interleukin-10 receptor subunit beta isoform 2 precursor
NM_001405850.1 NP_001392779.1 interleukin-10 receptor subunit beta isoform 3 precursor
NM_001406840.1 NP_001393769.1 interleukin-10 receptor subunit beta isoform 4 precursor

IL10RB Protein Structure

Tissue_fac

Tissue_fac: Tissue factor (13 - 100)

Interfer-bind

Interfer-bind: Interferon-alpha/beta receptor, fibronectin type III (111 - 213)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

interleukin-10 receptor subunit beta

IL-10 receptor subunit beta

Recombinant IL10RB Proteins

Cat. No. Product Name Accession Purity
HY-P72599 IL-10R beta Protein, Human (HEK293, His) Q08334/NP_000619.3 (M20-S220) ≥95%
HY-P74839 IL-10R beta Protein, Human (HEK293, His-hFc) Q08334 (M1-S220) ≥95%
HY-P74840 IL-10R beta Protein, Human (220a.a, HEK293, His) Q08334 (M1-S220) ≥95%

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 25, Autosomal Recessive

Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome

IBD25

Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive

Il10-Related Early-Onset Ibd

Il10-Related Early-Onset Inflammatory Bowel Disease

Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive

Autosomal Recessive Early-Onset Inflammatory Bowel Disease

Autosomal Recessive Early-Onset Ibd

Early-Onset Autosomal Recessive Inflammatory Bowel Disease

Bowel Disease, Inflammatory, Type 25, Autosomal Recessive
Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

Ibd25

Inflammatory Bowel Disease 25, Autosomal Recessive
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Colitis
Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis
Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Rubella

German Measles

Three Day Measles

Rubella Nos
Immunodeficiency 28

IMD28

Ifngr2 Deficiency

Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 28, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency

Msmd Due To Complete Ifngammar2 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency

Immunodeficiency, Type 28, Mycobacteriosis
Folliculitis
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Immunodeficiency 35

Tyrosine Kinase 2 Deficiency

IMD35

Tyk2 Deficiency

Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis

Susceptibility To Infection Due To Tyk2 Deficiency

Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive

Hies With Atypical Mycobacteriosis, Autosomal Recessive

Autosomal Recessiv Hies With Atypical Mycobacteriosis

Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency

Autosomal Recessive Hies With Atypical Mycobacteriosis
Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy

Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy

Ane

Acute Necrotizing Encephalopathy Type 1

Adane

Ane1

Autosomal Dominant Acute Necrotizing Encephalopathy

Iiae3

Susceptibility To Acute Necrotizing Encephalopathy

Susceptibility To Infection-Induced Acute Encephalopathy

Encephalopathy, Acute Necrotizing, Susceptibility To

Encephalitis, Acute Necrotizing
Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome

Fipa

Gastrointestinal Defects And Immunodeficiency Syndrome

Multiple Gastrointestinal Atresias

Familial Isolated Pituitary Adenoma

Intestinal Atresia, Multiple

Multiple Intestinal Atresia

GIDID1

Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Minat

Gidid

Meddra:10028210

Familial Isolated Pituitary Adenoma Syndrome

Intestinal Atresia Multiple

Combined Immunodeficiency-Enteropathy Spectrum

Cid-Mia/Early-Onset Ibd

Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Mia

Gastrointestinal Defect And Immunodeficiency Syndrome

Pituitary Adenoma Predisposition

Pituitary Adenoma, Familial Isolated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06674 IL10RB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL10RB RGD RGD:1560373
Bos taurus IL10RB VGNC VGNC:56219
Felis catus IL10RB VGNC VGNC:97463
Mus musculus IL10RB MGD MGI:109380