IL10RB - interleukin 10 receptor subunit beta Gene

Also Known as CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3588

About IL10RB

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,266,367-33,297,221 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three Other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

IL10RB Products (4)

mRNA	Protein	Name
NM_000628.5	NP_000619.3	interleukin-10 receptor subunit beta isoform 1 precursor
NM_001405849.1	NP_001392778.1	interleukin-10 receptor subunit beta isoform 2 precursor
NM_001405850.1	NP_001392779.1	interleukin-10 receptor subunit beta isoform 3 precursor
NM_001406840.1	NP_001393769.1	interleukin-10 receptor subunit beta isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	16982608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12483210	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	16982608	GOA
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	25930096	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	16982608	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL10RB Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
interleukin-10 receptor subunit beta	IL-10 receptor subunit beta

IL10RB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL10RB	Q08334	IL22RA1	Homo sapiens	Q8N6P7	ELISA	15120653

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL10RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72599	IL-10R beta Protein, Human (HEK293, His)	Q08334/NP_000619.3 (M20-S220)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74839	IL-10R beta Protein, Human (HEK293, His-hFc)	Q08334 (M20-S220)	≥ 90%, as determined by reducing SDS-PAGE.

IL10RB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84509	IL10RB Antibody (YA4206)	WB, FC, ELISA	Human, Rat
HY-P84509A	IL10RB Antibody (YA4206)(PBS only)	WB, FC, ELISA	Human, Rat
HY-P84510	IL10RB Antibody (YA4207)	ICC/IF, FC, ELISA	Human
HY-P84510A	IL10RB Antibody (YA4207)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 25, Autosomal Recessive	Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome IBD25 Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive Il10-Related Early-Onset Ibd Il10-Related Early-Onset Inflammatory Bowel Disease Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive Autosomal Recessive Early-Onset Inflammatory Bowel Disease Autosomal Recessive Early-Onset Ibd Early-Onset Autosomal Recessive Inflammatory Bowel Disease Bowel Disease, Inflammatory, Type 25, Autosomal Recessive
Inflammatory Bowel Disease 25	Early Onset Autosomal Recessive Inflammatory Bowel Disease 25 Ibd25 Inflammatory Bowel Disease 25, Autosomal Recessive
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Colitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Erythematosquamous Dermatosis	Other Erythematosquamous Dermatosis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Rubella	German Measles Three Day Measles Rubella Nos
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Folliculitis
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Acute Necrotizing Encephalitis	Acute Necrotizing Encephalopathy Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy Ane Acute Necrotizing Encephalopathy Type 1 Adane Ane1 Autosomal Dominant Acute Necrotizing Encephalopathy Iiae3 Susceptibility To Acute Necrotizing Encephalopathy Susceptibility To Infection-Induced Acute Encephalopathy Encephalopathy, Acute Necrotizing, Susceptibility To Encephalitis, Acute Necrotizing
Gastrointestinal Defects And Immunodeficiency Syndrome 1	Familial Intestinal Polyatresia Syndrome Fipa Gastrointestinal Defects And Immunodeficiency Syndrome Multiple Gastrointestinal Atresias Familial Isolated Pituitary Adenoma Intestinal Atresia, Multiple Multiple Intestinal Atresia GIDID1 Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Minat Gidid Meddra:10028210 Familial Isolated Pituitary Adenoma Syndrome Intestinal Atresia Multiple Combined Immunodeficiency-Enteropathy Spectrum Cid-Mia/Early-Onset Ibd Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Mia Gastrointestinal Defect And Immunodeficiency Syndrome Pituitary Adenoma Predisposition Pituitary Adenoma, Familial Isolated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06674	IL10RB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174657	Human IFNLR1 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990776	Vimekofusp		/	Unkown
HY-P992038	Anti-IL-10RB Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL10RB	RGD	RGD:1560373
Bos taurus	IL10RB	VGNC	VGNC:56219
Felis catus	IL10RB	VGNC	VGNC:97463
Mus musculus	IL10RB	MGD	MGI:109380
Others	IL10RB	NCBI