Il12a - interleukin 12a Gene

Also Known as p35; Ll12a; Il-12a; IL-12p35

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16159

About Il12a

Chromosome 3: 68,597,977-68,605,880 forward strand.GRCm39:CM000996.3

This gene has 6 transcripts (splice variants), 234 orthologues and is associated with 14 phenotypes.

Summary

Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]

Il12a Products (6)

mRNA Protein Name
NM_001159424.3 NP_001152896.2 interleukin-12 subunit alpha isoform 2 precursor
NM_001410419.1 NP_001397348.1 interleukin-12 subunit alpha isoform 5
NM_001410417.1 NP_001397346.1 interleukin-12 subunit alpha isoform 3 precursor
NM_001410418.1 NP_001397347.1 interleukin-12 subunit alpha isoform 4
NM_001410420.1 NP_001397349.1 interleukin-12 subunit alpha isoform 5
NM_008351.4 NP_032377.1 interleukin-12 subunit alpha isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to cytokine activity IDA
IDA: Inferred from direct assay
11057672 MGI
enables interleukin-12 beta subunit binding IPI
IPI: Inferred from physical interaction
15220916 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18033300 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
11057672 MGI
acts upstream of or within T-helper 1 cell activation IDA
IDA: Inferred from direct assay
22851706 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: Inferred from genetic interaction
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: Inferred from genetic interaction
15843532 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within defense response to protozoan IGI
IGI: Inferred from genetic interaction
9348310 MGI
acts upstream of or within positive regulation of T cell differentiation IGI
IGI: Inferred from genetic interaction
22968459 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11057672 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
21444916 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
9348310 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
21444916 MGI
acts upstream of type II interferon production IGI
IGI: Inferred from genetic interaction
9348310 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
20818394 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11737071 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
part of interleukin-12 complex IDA
IDA: Inferred from direct assay
15220916 MGI
part of interleukin-12 complex IGI
IGI: Inferred from genetic interaction
7690439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-12 subunit alpha

  • CLMF p35

  • IL-12 p35 subunit

  • IL-12 subunit p35

  • cytotoxic lymphocyte maturation factor 35 kDa subunit

  • interleukin 12a p35 subunit

  • interleukin-12 p35 subunit

Recombinant Il12a Proteins

Cat. No. Product Name Accession Purity
HY-P7208 IL-12 Protein, Mouse (CHO) P43431 (R23-A215)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70666 IL-12 Protein, Mouse (HEK293) P43431 (R23-A215)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73157 IL-12 Protein, Mouse (HEK293, Fc) P43431 (R23-A215)&P43432 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73158 IL-12 Protein, Mouse (HEK293, His-Fc) P43431 (R23-A215)&P43432 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73159 IL-12 Protein, Mouse (HEK293, His) P43431 (R23-A215)&P43432 (M23-S335) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700190AF Animal-Free IL-12 alpha Protein, Mouse (His) P43431 (R23-A215) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174642 Human IL12A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12a NCBI NCBI:3592