Lef1 - lymphoid enhancer binding factor 1 Gene

Also Known as Lef-1; 3000002B05

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16842

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian Cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lef1 Products (7)

mRNA Protein Name
NM_001276402.2 NP_001263331.1 lymphoid enhancer-binding factor 1 isoform b
NM_001276403.1 NP_001263332.1 lymphoid enhancer-binding factor 1 isoform c
NM_001379059.1 NP_001365988.1 lymphoid enhancer-binding factor 1 isoform d
NM_001379060.1 NP_001365989.1 lymphoid enhancer-binding factor 1 isoform e
NM_001379061.1 NP_001365990.1 lymphoid enhancer-binding factor 1 isoform f
NM_001379062.1 NP_001365991.1 lymphoid enhancer-binding factor 1 isoform g
NM_010703.5 NP_034833.2 lymphoid enhancer-binding factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7774816 MGI
enables DNA binding, bending EXP
EXP: Inferred from Experiment
15236581 MGI
enables DNA binding, bending IDA
IDA: Inferred from direct assay
7774816 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12244173 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11696550 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
15729346 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
30659184 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12244173 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15024079 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15545629 MGI
enables nucleic acid binding EXP
EXP: Inferred from Experiment
15236581 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11696550 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21750544 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
7537238 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
12551949 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell proliferation IMP
IMP: Inferred from mutant phenotype
10933391 MGI
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
9769173 MGI
acts upstream of or within T cell receptor V(D)J recombination IGI
IGI: Inferred from genetic interaction
9462507 MGI
involved in T-helper 1 cell differentiation IDA
IDA: Inferred from direct assay
18579517 MGI
acts upstream of or within alpha-beta T cell differentiation IGI
IGI: Inferred from genetic interaction
9462507 MGI
acts upstream of or within anatomical structure regression IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within apoptotic process involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
15649466 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
19154719 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
9769173 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
10933391 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16678815 MGI
acts upstream of or within cell development IGI
IGI: Inferred from genetic interaction
15729346 MGI
acts upstream of or within chorio-allantoic fusion IGI
IGI: Inferred from genetic interaction
10090727 MGI
acts upstream of or within dentate gyrus development IMP
IMP: Inferred from mutant phenotype
10631168 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
10090727 MGI
acts upstream of or within epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15649466 MGI
involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
17699607 MGI
acts upstream of or within forebrain neuroblast division IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within forebrain radial glial cell differentiation IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within formation of radial glial scaffolds IGI
IGI: Inferred from genetic interaction
14715945 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
10631168 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
16678815 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12551949 MGI
acts upstream of or within negative regulation of striated muscle tissue development IDA
IDA: Inferred from direct assay
16936075 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678101 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
17699607 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
12502739 MGI
acts upstream of or within paraxial mesoderm formation IGI
IGI: Inferred from genetic interaction
10090727 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10631168 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10933391 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
30659184 MGI
acts upstream of or within positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
30659184 MGI
involved in positive regulation of gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
23562159 MGI
involved in positive regulation of odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
29148101 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12475749 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12244173 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15094381 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20371816 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17284610 MGI
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23562159 MGI
acts upstream of or within regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
10090727 MGI
acts upstream of or within regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
19154719 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11696550 MGI
involved in secondary palate development IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within sensory perception of taste IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
10090727 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
15545629 MGI
acts upstream of or within sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
19154719 MGI
acts upstream of or within tongue development IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of or within trachea gland development IMP
IMP: Inferred from mutant phenotype
10498680 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
16163358 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
21075118 MGI
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
20371816 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14623238 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7537238 MGI
is active in nucleus IPI
IPI: Inferred from physical interaction
30659184 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
30659184 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
11696550 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphoid enhancer-binding factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07584 LEF1 Human Pre-designed siRNA Set A Pre-designed Set ≥90.0% Unkown
HY-181560 SLD1121 Agonist / Unkown
HY-RS18620 Lef1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25106 Lef1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lef1 NCBI NCBI:51176