Cygb - cytoglobin Gene

Also Known as Glnf; Stap; Staap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170520

Summary

Enables catalase activity; fatty acid peroxidase activity; and heme binding activity. Involved in several processes, including negative regulation of Collagen biosynthetic process; negative regulation of fibroblast migration; and negative regulation of hepatic stellate cell activation. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Cygb Products (1)

mRNA Protein Name
NM_130744.2 NP_570100.1 cytoglobin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables catalase activity IDA
IDA: Inferred from direct assay
11320098 RGD
enables fatty acid peroxidase activity IDA
IDA: Inferred from direct assay
11320098 RGD
enables heme binding IDA
IDA: Inferred from direct assay
11320098 RGD
enables nitric oxide dioxygenase activity, heme protein as donor IDA
IDA: Inferred from direct assay
28393874 RGD
enables peroxidase activity IDA
IDA: Inferred from direct assay
11320098 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid oxidation IDA
IDA: Inferred from direct assay
11320098 RGD
involved in negative regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
20719976 RGD
involved in negative regulation of fibroblast migration IDA
IDA: Inferred from direct assay
14647402 RGD
involved in negative regulation of hepatic stellate cell activation IDA
IDA: Inferred from direct assay
16581302 RGD
involved in nitric oxide catabolic process IMP
IMP: Inferred from mutant phenotype
28393874 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14660570 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
11320098 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14647402 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoglobin

  • HGb

  • globin f

  • histoglobin

  • stellate cell activation-associated protein

Recombinant Cygb Proteins

Cat. No. Product Name Accession Purity
HY-P72162 CYGB Protein, Rat (His-Myc) Q921A4 (M1-P190) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03432 CYGB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18031 Cygb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24505 Cygb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cygb NCBI NCBI:114757