Sgk3 - serum/glucocorticoid regulated kinase 3 Gene

Also Known as fy; fz; Cisk; 2510015P22Rik; A330005P07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170755

About Sgk3

Chromosome 1: 9,868,332-9,971,070 forward strand.GRCm39:CM000994.3

This gene has 12 transcripts (splice variants), 212 orthologues, 13 paralogues and is associated with 44 phenotypes. Broad expression in placenta adult (RPKM 7.), liver E14 (RPKM 4.9) and 19 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to several human genes including C8orf44-SGK3 (C8orf44-SGK3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Sgk3 Products (3)

mRNA Protein Name
NM_133220.2 NP_573483.1 serine/threonine-protein kinase Sgk3
NM_001037759.1 NP_001032848.1 serine/threonine-protein kinase Sgk3
NM_177547.3 NP_808215.2 serine/threonine-protein kinase Sgk3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
15126499 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11050396 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
11050396 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11050396 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sgk3 Protein Structure

PX_CISK

PX_CISK: cd06870 (11 - 119)

STKc_SGK3

STKc_SGK3: cd05604 (164 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Sgk3

  • cytokine-independent survival kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125878 PROTAC SGK3 degrader-1 Inhibitor 99.89% Unkown
HY-167832 PT109 Inhibitor 99.20% Unkown
HY-170933 SGK1-IN-6 Inhibitor / Unkown
HY-151009 308-R Inhibitor / Unkown
HY-W260045 1-Chloro-6-methoxyhexane Ligand / Unkown
HY-176823 PROTAC SGK3 degrader-2 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgk3 NCBI NCBI:23678